Benzazoles: benzoxazole, benzthiazole and benzimidazole derivatives

ABSTRACT

A compund of formula (I) wherein X is O or S; n is 0 or 1; Y is O, S or NR 7 ; R 1  is hydrogen, halogen, C 1-6  aklyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkylthio, C 1-6  haloalkylthio, C 3-6  cycloalkyl, C 1-6  alkoxy(C 1-6 )alkyl or SF 5 , R 2  is hydrogen, halogen, C 1-6  alkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkylthio, C 1-6  haloalkylthio, C 1-6  alkylsulfinyl, C 1-6  haloalkylsulfinyl, C 1-6  alkylsulfonyl, C 1-6  haloalkylsulfonyl, C 1-6  haloalkyl, cyano, nitro, CHO, CH═NOR 5 , C 1-6  alkylcarbonyl, C 1-6  alkoxycarbonyl or SF 5 ; or together R 1  and R 2  form a five or six membered saturated or unsturated carbocyclic ring, optionally substituted processes for preparing these compounds, compositions comprising them, methods of using them to combat fungal diseases and methods of using them to combat or control insect, acarine, mollusc and nematode pests.

[0001] The present invention relates to isothiazole derivatives, toprocesses for preparing them, to fungicidal, insecticidal, acaricidal,molluscicidal and nematicidal compositions comprising them, to methodsof using them to combat fungal diseases (especially fungal diseases ofplants) and to methods of using them to combat and control insect,acarine, mollusc and nematode pests.

[0002] Isothiazole derivatives are disclosed in WO 95/31448, WO97/18198, WO 98/02424 and WO 98/05670.

[0003] The present invention provides a compound of formula (I):

[0004] wherein X is O or S; n is 0 or 1; Y is O, S or NR⁷; R¹ ishydrogen, halogen, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₃₋₆ cycloalkyl, C₁₋₆alkoxy(C₁₋₆)alkyl or SF₅; R² is hydrogen, halogen, C₁₋₆ alkyl, C₁₋₆alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆haloalkylsulfonyl, C₁₋₆ haloalkyl, cyano, nitro, CHO, CH═NOR⁵, C₁₋₆alkylcarbonyl, C₁₋₆ alkoxycarbonyl or SF; or together R¹ and R² form afive or six membered saturated or unsaturated carbocyclic ring,optionally substituted by one or two C₁₋₆ allyl groups; R³ is hydrogen,C₁₋₆ alkyl, CH₂(C₁₋₄ haloalkyl), C₁₋₆ cyanoalkyl, C₃₋₆ alkenyl, C₃₋₆alkynyl, C₁₋₆ alkoxy(C₁₋₆)alkyl, C₁₋₆ alkylthio(C₁₋₆)alkyl, C₁₋₆alkoxy(C₁₋₆)alkoxy(C₁₋₆)alkyl, C₁₋₆ alkylcarbonyl, C₁₋₆ alkoxycarbonyl,formyl, C₁₋₆ alkylcarbonyl(C₁₋₆)alkyl, C₁₋₆ alkoxycarbonyl(C₁₋₆)alkyl,C₁₋₆ alkylaminocarbonyl, di(C₁₋₆)alkylanminocarbonyl, optionallysubstituted phenoxycarbonyl, optionally substituted phenyl(C₁₋₄)alkyl orS(O)_(q)R⁶; R⁴ is hydrogen, halogen, cyano, C₁₋₈ alkyl, C₁₋₆ haloalkyl,C₁₋₆ cyanoakyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₇ cycloalkyl, C₃₋₇halocycloalkyl, C₃₋₇ cyanocycloalkyl, C₁₋₃ alkyl(C₃₋₇)cycloalkyl, C₁₋₃alkyl(C₃₋₇)halocycloalkyl, C₃₋₆ cycloalkyl(C₁₋₆)alkyl, C₅₋₆cycloalkenyl, C₅₋₆cycloalkenyl(C₁₋₆)alkyl, C₂₋₆ haloalkenyl, C₁₋₆cyanoalkenyl, C₁₋₆ alkoxy(C₁₋₆)alkyl, formyl, C₁₋₆ carboxyalkyl, C₁₋₆alkylcarbonyl(C₁₋₆)alkyl, C₁₋₆ alkoxycarbonyl(C₁₋₆)alkyl, C₁₋₆alkylthio(C₁₋₆) alkyl, C₁₋₆ alkylsulfinyl(C₁₋₆)alkyl, C₁₋₆alkylsulfonyl(C₁₋₆)alkyl, aminocarbonyl(C₁₋₆)alkyl, C₁₋₆alkylaminocarbonyl(C₁₋₆)alkyl, di(C₁₋₆)alkylaninocarbonyl(C₁₋₆)alkyl,C₁₋₆ alkoxycarbonyl, C₁₋₆ alkylcarbonyl, aminocarbonyl, C₁₋₆alkylaminocarbonyl, di(C₁₋₆) alkylaminocarbonyl, optionally substitutedphenyl, optionally substituted phenyl(C₁₋₄ )alkyl, optionallysubstituted phenyl(C₂₋₄)alkenyl, optionally substituted heteroaryl,optionally substituted heteroaryl(C₁₋₄)alkyl, optionally substitutedheterocyclyl, optionally substituted heterocyclyl(C₁₋₄)alkyl, a groupOR⁸, a group SH, a group S(O)_(p)R⁹, a group NR¹⁰R¹¹ or a groupC(R¹²)=NOR¹³; R⁵ is hydrogen, C₁₋₆ alkyl, optionally substituted phenylor optionally substituted phenyl(C₁₋₄)alkyl; R⁶ is C₁₋₆ alkyl, C₁₋₆haloalkyl or optionally substituted phenyl; R⁷ is hydrogen, cyano, C₁₋₈alkyl, C₁₋₆ haloalkyl, C₁₋₆ cyanoalkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₇cycloalkyl, C₂₋₆ haloalkenyl, C₃₋₄ cycloalkyl(C₁₋₆)alkyl, C₁₋₆alkoxy(C₁₋₆)alkyl, ₁₋₆ alkoxycarbonyl, C₁₋₆ alkylcarbonyl, C₁₋₆alkylaminocarbonyl, di(C₁₋₆)alkylaminocarbonyl, optionally substitutedphenyl or optionally substituted heteroaryl; R⁸ is hydrogen, C₁₋₆ alkyl,C₁₋₆ haloalkyl, C₃₋₆ alkenyl, C₁₋₄ cyanoalkyl, C₁₋₆alkoxycarbonyl(C₁₋₆)alkyl, optionally substituted phenyl, optionallysubstituted phenyl(C₁₋₄)alkyl, optionally substituted heteroaryl,N═C(CH₃)₂; R⁹ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, cyano, C₁₋₄cyanoalkyl, C₁₋₆ alkoxycarbonyl(C₁₋₆)alkyl, optionally substitutedphenyl, optionally substituted phenyl(C,. ₄)alkyl or optionallysubstituted heteroaryl; R¹⁰ and R¹¹ are, indepently, hydrogen, C₁₋₈alkyl, C₃₋₇ cycloalkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₂₋₆ haloalkyl, C₁₋₆alkoxy(C₁₋₆)alkyl, C₁₋₆ alkoxycarbonyl, optionally substitutedphenoxycarbonyl, formyl, C₁₋₆ alkylcarbonyl, C₁₋₆ alkylSO₂, optionallysubstituted phenylSO₂ or optionally substituted phenyl(C₁₋₄)alkyl; R¹²is C₁₋₃ alkyl; R¹³ is C₁₋₆ alkyl, optionally substitutedphenyl(C₁₋₂)alkyl; and p and q are, independently, 0, 1 or 2.

[0005] The compounds of formula (I) may exist in different isomeric ortautomeric forms. This invention covers all such isomers and tautomersand mixtures thereof in all proportions.

[0006] In a further aspect the present invention provides a compound offormula (I) wherein X is O or S; n is 0 or 1; Y is O, S or NR⁷; R¹ ishydrogen, halogen, C₁₋₆ allyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆haloalkoxy, C₁₋₆ alkylthio, C₃₋₆ cycloalkyl or C₁₋₆ alkoxy(C₁₋₆)alkyl;R² is hydrogen, halogen, C₁₋₆ alkyl, C₁₋₆ haloalkyl, cyano, nitro, CHO,CH═NOR⁵, C₁₋₆ alkylcarbonyl, C₁₋₆ alkoxycarbonyl or C₁₋₆ alkylS(O)_(x);or together R¹ and R² form a five or six membered saturated orunsaturated carbocyclic ring, optionally substituted by one or two C₁₋₆alkyl groups; R³ is hydrogen, C₁₋₆ alkyl, CH₂(C₁₋₄ haloalkyl), C₃₋₆alkenyl, C₃₋₆ alkynyl, C₁₋₆ alkoxy(C₁₋₆)alkyl, C₁₋₆ alkylcarbonyl, C₁₋₆alkoxycarbonyl, formyl, optionally substituted phenoxycarbonyl,optionally substituted phenyl(C₁₋₄)allyl or S(O)_(y)R²⁵; R⁴ is hydrogen,halogen, cyano, optionally substituted alkyl, C₁₋₈ alkoxy, C₁₋₈haloalkoxy, C₁₋₈ alkylthio, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₇cycloalkyl(optionally substituted with halogen or C₁₋₆ alkyl), C₅₋₆ cycloalkenyl(optionally substituted with halogen or C₁₋₆ alkyl), C₂₋₆ haloalkenyl,NHSO₂R²⁴, NHCOR²⁴, CONR²⁰R²¹, NR²⁰R²¹, COR²⁴, CO₂R²⁰, optionallysubstituted phenyl, optionally substituted heteroaryl or a group ZR²⁶;R⁵ is hydrogen, C₁₋₆ alkyl, optionally substituted phenyl or optionallysubstituted phenyl(C₁₋₄)alkyl; R²⁵ is C₁₋₆ alkyl, C₁₋₆ haloalkyl oroptionally substituted phenyl; Z is O, S, SO, SO₂ or NR²⁷; R⁷ ishydrogen, cyano, C₁₋₈ alkyl, C₁₋₆ haloalkyl, C₁₋₆ cyanoalkyl, C₂₋₆alkenyl, C₂₋₆ alkynyl, C₃₋₇ cycloalkyl, C₂₋₆ haloalkenyl, C₃₋₆cycloalkyl(C₁₋₆)alkyl, C₁₋₆ alkoxy(C₁₋₆)alkyl, C₁₋₆ alkoxycarbonyl, C₁₋₆alkylcarbonyl, C₁₋₆ alkylaminocarbonyl, di(C₁₋₆)alkylaminocarbonyl,optionally substituted phenyl or optionally substituted heteroaryl; R²⁶and R²⁷ are, independently, hydrogen, C₁₋₈ alkyl, C₃₋₆ alkenyl, C₃₋₆alkynyl, C₁₋₆ alkoxy(C₁₋₆)alkyl, C₁₋₆ alkoxycarbonyl, optionallysubstituted phenoxycarbonyl, C₁₋₆ alkylcarbonyl or optionallysubstituted phenyl(C₁₋₄)alkyl, or R²⁶ and R²⁷ join to form a 5- or6-membered saturated or unsaturated ring optionally containing anotherheteroatom selected from oxygen, sulfur and nitrogen; R²⁰ and R²¹ are,independently, hydrogen or C₁₋₆ alkyl; R²⁴ is C₁₋₆ alkyl or phenyl; andx and y are, independently, 0, 1 or 2.

[0007] Alkyl is straight or branched chain and is, for example, methyl,ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, iso-propyl, n-butyl,sec-butyl, iso-butyl, tert-butyl or neo-pentyl.

[0008] Halogen is fluorine, chlorine, bromine or iodine.

[0009] Haloalkyl groups are alwyl groups which are optionallysubstituted with one or more of the same or different halogen atoms andare, for example, CF₃, CH₂CF₃ or CH₂CHF₂.

[0010] Phenyl(C₁₋₄)alkyl is, for example, 1-phenyleth-1-yl,2-phenyleth-1-yl, 2-phenylprop-2-yl, 3-phenylprop-1-yl, but ispreferably benzyl. The term heteroaryl refers to an aromatic ringcontaining one or more heteroatoms (preferably one or two heteroatoms)selected from O, S and N. Examples of such rings include pyridine,pyrnmidine, furan, quinazoline, thiophene, thiazole, oxazole andisoxazole.

[0011] The term heterocyclyl refers to a non-aromatic ring containingone or more (preferably one or two) heteroatoms selected from O, S andN. Examples of such rings include 1,3-dioxolanyl, tetrrhydrofrryl andmorpholinyl. It is preferred that heterocyclyl is optionally substitutedby C₁₋₆ alkyl.

[0012] Cycloalkenyl includes cyclopentenyl, cyclohexenyl andcyclohexadienyl.

[0013] It is preferred that phenyl moieties and heteroaryl groups areoptionally substituted by one or more substituents independentlyselected from halogen, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆alkoxy(C₁₋₆)alkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆aIkylsulfonyl, C₁₋₆ haloalkylsulfonyl, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl,C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, nitro, cyano, CO₂H, C₁₋₆ alkylcarbonyl,C₁₋₆ alkoxycarbonyl, R¹⁴R¹⁵N or R¹⁶R¹⁷NC(O); wherein R¹⁴, R¹³, R¹⁶ andR¹⁷ are, independently, hydrogen or C₁₋₆ allyl.

[0014] It is preferred that R¹ is C₁₋₂ alkyl, especially, methyl.

[0015] It is preferred that R² is hydrogen, cyano or halogen,especially, halogen (especially bromo or chloro).

[0016] It is preferred that R³ is hydrogen, C₁₋₆ alkyl or C₁₋₆alkoxy(C₁₋₆)alkyl.

[0017] It is further preferred that R³ is hydrogen, ethyl orethoxymethyl.

[0018] It is preferred that R⁴ is C₁₋₆ alkoxy(C₁₋₆)alkyl, C₁₋₆haloalkyl, (C₁₋₆ alkyl)amino, di-(C₁₋₆ alkyl)amino (such as N(C₂H₅)₂ orN(C₂H₅)(CH[CH₂]CH₃)), morpholino, C₁₋₆ alkyl or C₁₋₆ alkoxy, especiallymorpholino, C₁₋₆ alkyl or C₁₋₆ alkoxy.

[0019] It is preferred that n is 0.

[0020] It is preferred that X is oxygen.

[0021] It is preferred that Y is oxygen or sulphur.

[0022] It is preferred that the compounds -of the invention are offormula (Ia).

[0023] In one particular aspect the present invention provides acompound of formula (Ia) wherein R¹ is C₁₋₄ alkyl (especially methyl orethyl); R² is hydrogen, halogen (especially chloro or bromo) or cyano;or R¹ and R² together form a cyclopentyl, cyclohexyl or phenyl ring; R³is hydrogen, C₁₋₄ alkyl (especially methyl or ethyl), C₁₋₆ alkenyl(especially allyl), C₁₋₆ alkynyl (especially propargyl), or C₁₋₆alkoxy(C₁₋₆)alkyl (especially methoxymethyl and ethoxymethyl); n is 0; Xand Y are both oxygen; and R⁴ is C₁₋₆ alkyl [optionaly substituted withhalogen, C₁₋₄ alkoxy, C₁₋₄ alkylthio, C₁₋₄ haloalkylthio, alkylamino,dialkylamino (wherein the alkyl groups may form part of a five orsix-membered ring, optionally containing one heteroatom such as oxygenor nitrogen), phenyl (itself optionally substituted with halogen), C₃₋₆cycloalkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₃₋₆ cycloalkyl, phenyl[optionally substituted with halogen, C₁₋₄ haloalkyl (especially CF₃),nitro, CO₂H, or cyano] or heteroaryl (especiallypyridyl or pyrimidinyl)[optionally substituted with C₁₋₄ alkyl or C₁₋₄ haloalkyl]].

[0024] In one particular aspect the present invention provides acompound of formula (Ia) wherein R¹ is C₁₋₄alkyl (especially methyl orethyl); R² is hydrogen, halogen (especially chloro or bromo) or cyano;or R¹ and R² together form a cyclopentyl, cyclohexyl or phenyl ring; R³is hydrogen, C₁₋₄ alkyl (especially methyl or ethyl), phenyl(C₁₋₄)alkyl(especially benzyl), C₁₋₄ alkylcarbonyl (especially acetyl) or C₁₋₄alkylsulfonyl (especially methanesulfonyl); n is 0; X is oxygen; Y isoxygen or sulphur (especially oxygen); R⁴ is hydrogen, C₁₋₈ alkyl[optionally substituted with halogen, C₁₋₄ alkoxy, C₄ alkylS(O)_(m),phenyl (itself optionally substituted with halogen), phenoxy, NR²⁰R²¹,CO₂H, CONR²²R²³, cyano, C₃₋₆ cycloalkyl or CO(C₁₋₆ alkoxy)], C₁₋₈ alkoxy(optionally substituted with halogen), C₁₋₈ alkylthio, C₂₋₈ alkenyl(optionally substituted with halogen), NHSO₂R²⁴, NHCOR²⁴, NR²⁰R²¹,COR²⁴, CO₂R²⁰, C₂₋₈ alkynyl, C₃₋₆ cycloalyl (optionally substituted withhalogen or C₁₋₆ alkyl), C₅₋₆ cycloalkenyl, phenyl [optionallysubstituted with halogen, C₁₋₄haloalkyl (especially CF₃), C₁₋₄ alkoxy,nitro, CO₂R²⁰ or cyano] or heteroaryl (especially pyridyl, pyrimidinyl,furanyl or thiophenyl) [optionally substituted with C₁₋₆ alkyl, nitro orC₁₋₄ haloalkyl]; R²⁰, R²¹, R²² and R²³ are, independently, hydrogen orC₁₋₄ alkyl; R²⁴ is C₁₋₄ alkyl or phenyl; and m is 0, 1 or 2.

[0025] The physical parameter K concerns the relative solubility of acompound in n-octanol and water and, for a compound [A]:$K_{o/w} = \frac{\left( {{solubiltiy}\quad {of}\quad {{compound}\quad\lbrack A\rbrack}\quad {in}\quad n\text{-}{octanol}} \right)}{\left( {{solubility}\quad {of}\quad {{compound}\quad\lbrack A\rbrack}\quad {in}\quad {water}} \right)}$

[0026] In a further aspect the present invention provides a compound offormula (I) wherein log₁₀K_(o/w) (calculated using the CLOGP3 program,available from BioByte Corp.,201 West 4th Street, Suite 204, Claremont,Calif. 91711, USA) of the compound is in the range zero to 8, preferablyin the range 1 to 6 and more preferably in the range 1.2 to 5.2.

[0027] It will readily be seen that the side chain portion of formula(XIX):

[0028] is a portion of a compound of formula (I). The longest bond pathof the side chain portion of formula (XIX) is the path involving theminimum number of bonds from the carbon labelled # to the furthest atomof the side chain, having an atomic weight greater than 10 Daltons. Ifthere is more than one longest bond path, each involving the sameminimum number of bonds, there is a set of longest bond paths.

[0029] In a further aspect of the present invention it is preferred thatR⁴ is hydrogen, SH, C₁₋₆ alkyl, C₃₋₆ cycloalyl, C₂₋₆ alkenyl, C₂₋₅alkynyl, C₁₋₄ haloalkyl, C₁₋₄ cyanoalkyl, C₂₋₆ haloalkenyl, optionallysubstituted heterocyclyl(C₁₋₄)alkyl, C₂₋₆ cyanoalkenyl (such as1-cyano-2-methylpropenyl), phenyl (optionally substituted with fluoro,chloro, bromo, nitro, cyano, C₁₋₆ alkyl, C₁₋₂ alkoxy, C₁₋₄ haloalkyl(such as trifluoromethyl), C₁₋₄ haloalkoxy (such as trifluoromethoxy),methanesulfonyl, methylenedioxy or di(C₁₋₄ alkyl)amino (such asdimethylamino)), phenyl(C₁₋₃)alkyl (phenyl optionally substituted withhalogen, nitro, cyano, C₁₋₆ alkyl, C₁₋₂ alkoxy, C₁₋₄ haloalkyl (such astrifluoromethyl), C₁₋₄ haloalkoxy (such as trifluoromethoxy),methanesulfonyl, or methylenedioxy), formyl, optionally substitutedheterocyclyl, optionally substituted heteroaryl, optionally substitutedheteroaryl(C₁₋₄)alkyl, C₁₋₂ alkylcarbonyl, C₁₋₄ alkoxycarbonyl, C₁₋₅alkoxycarbonyl(C₁,)4alkyl, a group NR¹⁰R¹¹, a group OR⁸, C₁₋₄alkoxymethyl, chlorine, a group SR⁹, or a group C(R¹²)═NOR¹³; R⁸ ishydrogen, C₁₋₅ alkyl, C₁₋₄ haloalkyl (such as 2,2,2-trifluoroethyl),C₂₋₄ alkenyl (such as allyl), phenyl (optionally substituted withfluoro, chloro, bromo, nitro, cyano, C₁₋₆ alkyl, C₁₋₂ alkoxy, C₁₋₄haloalkyl (such as trifluoromethyl), C₁₋₄ haloalkoxy (such astrifluoromethoxy), methanesulfonyl, or methylenedioxy), phenyl(CH)(phenyl optionally substituted with fluoro, chloro, bromo, nitro, cyano,C₁₋₆ alkyl, C₁₋₂ alkoxy, C₁₋₄ haloalkyl (such as trifluoromethyl), C₁₋₄haloalkoxy (such as trifluoromethoxy), methanesulfonyl, ormethylenedioxy), N═C(CH₃)₂; R⁹ is C₁₋₅ alkyl, phenyl (optionallysubstituted with fluoro, chloro, bromo, nitro, cyano, C₁₋₆ alkyl, C₁₋₂alkoxy, C₁₋₄ haloalkyl (such as trifluoromethyl), C₁₋₄ haloalkoxy (suchas trifluoromethoxy), methanesulfonyl, methylenedioxy or di(C₁₋₄alkyl)amino (such as dimethylamino)), C₁₋₂ haloalkyl, cyano, cyanomethylor C₁₋₂ alkoxycarbonylmethyl; R¹⁰ and R¹¹ are, independently, hydrogen,C₁₋₄ alkyl, C₅₋₆ cycloalkyl, formyl, C₁₋₃alkylcarbonyl, phenoxycarbonyl,C₁₋₂ alkylSO₂ or phenylSO₂; R¹² is C₁₋₂ alkyl; R¹³ is C₁₋₂ alkyl orbenzyl; heterocyclyl is, for example, tetrahydrofuryl, 1,3-dioxolanyl ormorpholinyl; an example of an optional substituent for heterocyclyl isC₁₋₄ alkyl; heteroaryl is, for example, thienyl, furyl, pyridyl,quinazolinyl, pyrazolyl or isoxazolyl; and examples of optionalsubstituents for heteroaryl include C₁₋₆ alkyl, C₁₋₆ haloalkyl andphenoxy.

[0030] In a further aspect the present invention provides a compound offormula (I) wherein the side chain portion of formula (XIX) is such thateach atom having an atomic weight greater than 10 Daltons in the sidechain portion is no more than four bond lengths away from any of theatoms present in the longest bond path or one of the longest bond paths.

[0031] In another aspect the present invention provides a compound offormula (Ia) or (Ib) wherein R¹ is C₁₋₂ alkyl, chloro, CF₃, OCH₃ orSCH₃; R² is hydrogen, halogen (such as fluorine, chlorine or bromine),cyano, nitro, C₁₋₄alkyl (such as methyl), C₁₋₄alkoxy (such methoxy) orSCH₃; or R¹ and R² join to form a C₃₋₇cycloalkyl (such as cyclopentyl orcyclohexyl) or phenyl ring; R³ is hydrogen, C₁₋₆ alkyl optionallysubstituted with cyano, halogen, (C₁₋₆)alkoxy, (C₁₋₆)alkoxy(C₁₋₄)alkoxy,C₁₋₄alkoxycarbonyl, phenyl or C₁₋₄ alkylthio (such as methyl, ethyl,n-propyl, iso-propyl, cyanomethyl, 2,2,2-trifluoroethyl,(C₁₋₂)alkoxymethyl, methoxyethoxymethyl, methoxycarbonylmethyl,phenylmethyl or methylthiomethyl), C₃₋₆ alkenyl (such as allyl), C₃₋₆alkynyl (such as propargyl), carbonyl substituted with C₁₋₆alkoxy,C₁₋₄alkylamino or di(C₁₋₄alkyl)amino (such as C₁₋₂ alkoxycarbonyl,methylaminocarbonyl or dimethylaminocarbonyl), C₁₋₄alkylthio (such asmethylthio) or phenylthio; X is oxygen or sulphur; Y is oxygen, sulphuror NR⁷; n is 0; R⁴ is hydrogen, SH, C₁₋₆ alkyl, C₃₋₆ cycloalkyl, C₂₋₆alkenyl, C₂₋₅ alkynyl, C₁₋₄ haloalkyl, C₁₋₄ cyanoalkyl, C₂₋₆haloalkenyl, optionally substituted heterocyclyl(C₁₋₄)allyl,1-cyano-2-methylpropenyl, phenyl (optionally substituted with fluoro,chloro, bromo, nitro, cyano, C₁₋₂ alkyl, tert-butyl, C₁₋₂ alkoxy,trifluoromethyl, trifluoromethoxy, methanesulfonyl, methylenedioxy ordimethylamino), phenyl(C₁₋₃)alkyl (phenyl optionally substituted withfluorine), formyl, optionally substituted heteroyclyl, optionallysubstituted heteroaryl, optionally substituted heteroaryl(C₁₋₄)alkyl,C₁₋₂ alkylcarbonyl, C₁₋₄ alkoxycarbonyl, C₁₋₅ alkoxycarbonyl(C₁₋₄)alkyl,a group NR¹⁰R¹¹, a group OR⁸, C₁₋₄ alkoxymethyl, chlorine, a group SR⁹,or a group C(R¹²)═NOR¹³; R⁷ is hydrogen or C₁₋₄alkyl (such as methyl);R⁸ is hydrogen, C₁₋₅ alkyl, 2,2,2-trifluoroethyl, allyl, phenyl(optionally substituted with chloro), phenyl(CH₂) (phenyl optionallysubstituted with fluoro, chloro), N═C(CH₃)₂; R⁹ is C₁₋₅ alkyl, phenylC₁₋₂haloalkyl, cyano, cyanomethyl or C₁₋₂ alkoxycarbonylmethyl; R¹⁰ andR¹¹ are, independently, hydrogen, C₁₋₄alkyl, C₅₋₆ cycloalkyl, formyl,C₁₋₃ alkylcarbonyl, phenoxycarbonyl, C₁₋₂ alkylSO₂ or phenylSO₂; R¹² isC₁₋₂ alkyl; R¹³ is C₁₋₂alkyl or benzyl; heterocyclyl is, for example,tetrahydrofuryl, 1,3-dioxolanyl or morpholinyl; an example of anoptional substituent for heterocyclyl is C₁₋₄alkyl; heteroaryl is, forexample, thienyl, furyl, pyridyl, quinazolinyl, pyrazolyl or isoxazolyl;and examples of optional substituents for heteroaryl include C₁₋₆ alkyl,C₁₋₆ haloalkyl and phenoxy. Specific preferred values of R⁴ are recitedin Table A1.

[0032] The compounds in the following Tables illustrate compounds of theinvention. Table A1 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is hydrogen; X and Y are each oxygen; n is 0;and R⁴ is as defined in the Table. TABLE A1 Compound Number R⁴ 1 H 2 CH₃3 CH₂CH₃ 4 CH₂CH₂CH₃ 5 CH₂CH₂CH₂CH₃ 6 CH₂CH₂CH₂CH₂CH₃ 7CH₂CH₂CH₂CH₂CH₂CH₃ 8 CH(CH₃)₂ 9 C(CH₃)₃ 10 CH(CH₃)CH₂CH₃ 11CH₂CH(CH₃)CH₂CH₃ 12 CH(CH₃)CH₂CH₂CH₃ 13 CH(CH₂CH₃)₂ 14 CH₂CH(CH₃)₂ 15CH₂C(CH₃)₃ 16 CH₂CH₂CH(CH₃)₂ 17 CH₂CH₂C(CH₃)₃ 18 C(CH₃)₂CH₃ 19C(CH₃)₂CH₂CH₃ 20 C(CH₃)₂CH₂CH₂CH₃ 21 cyclopropyl 22 1-methylcyclopropyl23 2-methylcyclopropyl 24 1-cyanocyclopropyl 252,2-dichloro-3,3-dimethylcyclopropyl 262,2-dichloro-1-ethyl-3-methylcyclopropyl 27 cyclobutyl 28 cyclopentyl 291-methylcyclopentyl 30 1-cyclopentenyl 31 2-cyclopentenyl 323-cyclopentenyl 33 2-cyclopentenylmethyl 34 1-cyclopentenylmethyl 35cyclohexyl 36 1-methylcyclohexyl 37 1-cyclohexenyl 38 2-cyclohexenyl 39cyclohexylmethyl 40 2-cyclohexenylmethyl 41 cyclopropylmethyl 42cyclopentylmethyl 43 2-cyclopentylethyl 44 CH═CH₂ 45 CH═CHCH₃ 46CH═C(CH₃)₂ 47 C(CH₃)═CHCH₃ 48 CH═CHCH₂CH₂CH₃ 49 C(CH₃)═C(CH₃)₂ 50CH═CHCH(CH₃)₂ 51 CH₂CH═CH₂ 52 CH₂CH═CHCH₃ 53 CH₂CH═C(CH₃)₂ 54CH₂C(CH₃)═CH₂ 55 CH₂C(CH₃)═CHCH₃ 56 CH₂C(CH₃)═C(CH₃)₂ 57 CH₂CH₂CH═CH₂ 58C(CH₃)═CHCH₃ 59 C(CH₃)₂CH═CH₂ 60 C(CH₃)═CHCH₂CH₃ 61 CH═CHCH═CHCH₃ 62cyclopentyldienyl 63 4-nitrostyryl 64 C≡CH 65 C≡CCH₃ 66 C≡CCH₂CH₃ 67CH₂C≡CH 68 CH(CH₃)C≡CH 69 C(CH₃)₂C≡CH 70 CH₂CH₂C≡CH 71 CH₂CH₂C≡CCH₃ 72CH₂CH₂COCH₃ 73 CH₂F 74 CHF₂ 75 CF₃ 76 CF(CH₃)₂ 77 CH₂CF₃ 78 CF₂CF₃ 79CF₂CHF₂ 80 CF₂CF₂CF₃ 81 CF₂CF₂CF₂CF₃ 82 CF═CFCF₂CF₃ 83 CF₂Cl 84 CF₂Br 85CFClCF₃ 86 CF₂CF₂Cl 87 CF₂CFClCF₃ 88 CFBrCF₃ 89 CH₂Cl 90 CH₂CH₂Cl 91CH₂CH₂CH₂Cl 92 CH₂CH₂CH₂CH₂Cl 93 CH(Cl)CH₃ 94 CH(Cl)—C₆H₅ 95CH(Cl)CH₂CH₃ 96 CH(Cl)CH₂Cl 97 CCl(CH₃)₂ 98 C(CH₃)₂CH₂Cl 99 CHCl₂ 100C(CH₂Cl)₂CH₃ 101 C(CH₃)₂CHCl₂ 102 CH₂CH(Cl)CH₃ 103 CCl₃ 104 CCl₂CCl₃ 105CH═CHCl 106 CCl═CH₂ 107 CCl═CCl₂ 108 CH₂Br 109 CHBr₂ 110 C(CH₃)₂Br 111CH(Br)CH(CH₃)₂ 112 C(CH₃)BrCH₂Br 113 CH₂CN 114 CH₂CH₂CN 115 CH(CH₃)CN116 C(CH₃)₂CN 117 CH₂CH(CH₃)CN 118 CH₂C(CH₃)₂CN 119 C(CN)═C(CH₃)₂ 120CH₂CO₂CH₃ 121 CH₂CO₂CH₂CH₃ 122 CH₂CO₂C(CH₃)₃ 123 CH(CH₃)CO₂CH₃ 124CH(CH₃)CO₂CH₂CH₃ 125 CH(CH₃)CO₂C(CH₃)₃ 126 C(CH₃)₂CO₂CH₃ 127C(CH₃)₂CO₂CH₂CH₃ 128 C(CH₃)₂CO₂C(CH₃)₃ 129 CH₂C(CH₃)₂CH₂CO₂CH₂CH₃ 130CH₂OCH₃ 131 CH₂OCH₂CH₃ 132 CH₂CH₂OCH₃ 133 CH₂OCH(CH₃)₂ 134 CH₂OC(CH₃)₃135 C(CH₃)₂OCOCH₃ 136 C(CH₃)₂OH 137 CH₂OCH₂CH₂OCH₃ 138 CH₂OCH₂CH₂OCH₂CH₃139 CH₂CH₂OH 140 CH₂O—C₆H₅ 141 CH(CH₃)O—C₆H₅ 1421-methyl-1-(4-chlorophenoxy)ethyl 143 2-nitrophenoxymethyl 1444-nitrophenoxymethyl 145 2-tetrahydrofuryl 146 3-tetrahydrofuryl 1472-tetrahydrofurylmethyl 148 3-tetrahydrofurylmethyl 149(1,3-dioxolan-2-yl)methyl 150 (2-methyl-1,3-dioxolan-2-yl)methyl 151(1,3-dioxolan-4-yl)methyl 152 (2-methyl-1,3-dioxolan-4-yl)methyl 153 CHO154 COCH₃ 155 COCH₂CH₃ 156 CO₂CH₃ 157 CO₂CH₂CH₃ 158 CO₂CH(CH₃)₂ 159CO₂C(CH₃)₃ 160 CO₂C(CH₃)₂CH₂CH₃ 161 CH₂CH₂CO₂H 162 CH₂CH₂CO₂CH₃ 163CH₂CH₂CO₂CH₂CH₃ 164 CH₂CH₂CH₂CO₂CH₃ 165 CH₂CH₂CH₂CO₂CH₂CH₃ 166 CH═NOH167 C(CH₃)═NOCH₃ 168 C(CH₃)═NOH 169 C(CH₃)═NOCH₃ 170 C(CH₃)═NOCH₂—C₆H₅171 CH₂SCH₃ 172 CH₂CH₂SCH₃ 173 CH₂S—C₆H₅ 174 Cl 175 NH₂ 176 NHCH₃ 177NHCH₂CH₃ 178 NHCH₂CH₂CH₃ 179 N(CH₃)₂ 180 N(CH₃)CH₂CH₃ 181 N(CH₂CH₃)₂ 182NHCH(CH₃)₂ 183 NHC(CH₃)₃ 184 N(CH₃)CH(CH₃)₂ 185 N(CH₃)C(CH₃)₃ 186NH-cyclopentyl 187 NH-cyclohexyl 188 N(CH₃)-cyclopentyl 189N(CH₃)-cyclohexyl 190 N(CH₂CH₃)-cyclohexyl 191 morpholino 192 NHCHO 193NHCOCH₃ 194 NHCOCH₂CH₃ 195 NHCOCH(CH₃)₂ 196 NHCO—C₆H₅ 197 N(CH₃)CHO 198N(CH₃)COCH₃ 199 N(CH₃)COCH₂CH₃ 200 NHSO₂CH₃ 201 NHSO₂CH₂CH₃ 202NHSO₂—C₆H₅ 203 OCH₃ 204 OCH₂CH₃ 205 OCH₂CH₂CH₃ 206 OCH(CH₃)₂ 207OC(CH₃)₃ 208 OCH₂CH(CH₃)₂ 209 OCH(CH₃)CH₂CH₃ 210 OCH₂CF₃ 211 OCH₂C(CH₃)₃212 OCH₂—C₆H₅ 213 4-fluorobenzyloxy 214 2,4-dichlorobenzyloxy 215OCH₂CH═CH₂ 216 O—C₆H₅ 217 2-chlorophenoxy 218 4-chlorophenoxy 219O—N═C(CH₃)₂ 220 SCH₃ 221 SCH₂CH₃ 222 S(CH₂)₂CH₃ 223 SCH(CH₃)₂ 224SC(CH₃)₃ 225 SCH₂CH(CH₃)₂ 226 SCH₂C(CH₃)₃ 227 S—C₆H₅ 228 SCH₂CN 229SCH₂CO₂CH₃ 230 SCH₂CO₂CH₂CH₃ 231 SCHF₂ 232 SCF₃ 233 SCH₂CF₃ 234 SCF₂CF₂H235 SCN 236 CH₂C₆H₅ 237 CH(CH₃)C₆H₅ 238 C(CH₃)₂C₆H₅ 239 CH₂C₆F₅ 2403,5-diF—C₆H₃ 241 3-CH₃O—C₆H₄ 242 4-F—C₆H₄ 243 4-F—C₆H₄ 2442,6-diCl-4-CF₃—C₆H₂ 245 CH(CH₂CH₃)C₆H₅ 246 CH(C₆H₅)₂ 247 CH₂CH₂C₆H₅ 248C₆H₅ 249 2-Br—C₆H₄ 250 3-Br—C₆H₄ 251 4-Br—C₆H₄ 252 4-tert-butyl-C₆H₄ 2532-Cl—C₆H₄ 254 3-Cl—C₆H₄ 255 4-Cl—C₆H₄ 256 2,3-diCl—C₆H₃ 2572,4-diCl—C₆H₃ 258 2,5-diCl—C₆H₃ 259 2,6-diCl—C₆H₃ 260 3,4-diCl—C₆H₃ 2613,5-diCl—C₆H₃ 262 2,4,6-triCl—C₆H₂ 263 C₆Cl₅ 264 2-Cl-4-F—C₆H₃ 2652-Cl-6-F—C₆H₃ 266 4-Cl-2,5-diF—C₆H₂ 267 2-Cl-4-NO₂—C₆H₃ 2682-Cl-4-CF₃—C₆H₃ 269 2-Cl-6-CF₃—C₆H₃ 270 2-Cl-4-methanesulfonyl-C₆H₃ 2712,4-diCl-5-F—C₆H₂ 272 2-F—C₆H₄ 273 3-F—C₆H₄ 274 4-F—C₆H₄ 2752,3-diF—C₆H₃ 276 2,4-diF—C₆H₃ 277 2,5-diF—C₆H₃ 278 2,6-diF—C₆H₃ 2793,4-diF—C₆H₃ 280 3,5-diF—C₆H₃ 281 2,3,4-triF—C₆H₂ 282 2,3,5-triF—C₆H₂283 2,3,6-triF—C₆H₂ 284 2,4,6-triF—C₆H₂ 285 3,4,5-triF—C₆H₂ 2862,3,4,5-tetraF—C₆H 287 C₆F₅ 288 2-F-3-CF₃—C₆H₃ 289 2-F-4-CF₃—C₆H₃ 2902-F-5-CF₃—C₆H₃ 291 2-F-6-CF₃—C₆H₃ 292 4-F-2-CF₃—C₆H₃ 293 4-F-3-CF₃—C₆H₃294 5-F-2-CF₃—C₆H₃ 295 2-CN—C₆H₄ 296 3-CN—C₆H₄ 297 4-CN—C₆H₄ 2984-dimethylaminophenyl 299 2-C₂H₅O—C₆H₄ 300 3-C₂H₅O—C₆H₄ 301 4-C₂H₅O—C₆H₄302 2-C₂H₅—C₆H₄ 303 3-C₂H₅—C₆H₄ 304 4-C₂H₅—C₆H₄ 305 2-CH₃O—C₆H₄ 3063-CH₃O—C₆H₄ 307 4-CH₃O—C₆H₄ 308 3,4-diCH₃O—C₆H₃ 309 3,5-diCH₃O—C₆H₃ 3102,6-diCH₃O—C₆H₃ 311 3,4-(methylenedioxy)phenyl 312 2-CH₃—C₆H₄ 3133-CH₃—C₆H₄ 314 4-CH₃—C₆H₄ 315 2,3-diCH₃—C₆H₃ 316 2,4-diCH₃—C₆H₃ 3172,5-diCH₃—C₆H₃ 318 2,6-diCH₃—C₆H₃ 319 3,4-diCH₃—C₆H₃ 3202,4,6-triCH₃—C₆H₂ 321 2-NO₂—C₆H₄ 322 3-NO₂—C₆H₄ 323 4-NO₂—C₆H₄ 3244-methanesulfonyl-2-nitrophenyl 325 3-trifluoromethoxyphenyl 3262-trifluoromethylphenyl 327 3-trifluoromethylphenyl 3284-trifluoromethylphenyl 329 4-carboxymethylphenyl 330 2-thienyl 3313-chloro-2-thienyl 332 3,4,5-trichloro-2-thienyl 333 2-benzothiophenyl334 2-thienylmethyl 335 5-tert-butyl-2-furyl 336 5-nitro-2-furyl 337pyridin-2-yl 338 pyridin-3-yl 339 pyridin-4-yl 340 3-chloro-2-pyridyl341 6-chloro-2-pyridyl 342 2,6-dichloro-4-pyridyl 343 2-chloro-3-pyridyl344 2-phenoxy-3-pyridyl 345 2-quinazolinyl 346 4-biphenyl 3471,3-dimethyl-5-pyrazolyl 348 4-chloro-1,3-dimethyl-5-pyrazolyl 3495-isoxazolyl 350 6-trifluoromethyl-2-pyridyl 351 OH 352 SH

TABLE A2

[0033] Table A2 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is hydrogen; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A3

[0034] Table A3 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is hydrogen; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A4

[0035] Table A4 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is hydrogen; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A5

[0036] Table A5 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is hydrogen; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A6

[0037] Table A6 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is hydrogen; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A7

[0038] Table A7 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is hydrogen; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A8

[0039] Table A8 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is hydrogen; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A9

[0040] Table A9 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is hydrogen; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE A10

[0041] Table A10 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is hydrogen; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLEA11

[0042] Table A11 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is hydrogen; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A12

[0043] Table A12 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is hydrogen; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A13

[0044] Table A13 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is hydrogen; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A14

[0045] Table A14 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is hydrogen; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A15

[0046] Table A15 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is hydrogen; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A16

[0047] Table A16 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is hydrogen; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A17

[0048] Table A17 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is hydrogen; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A18

[0049] Table A18 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is hydrogen; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A19

[0050] Table A19 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is hydrogen; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A20

[0051] Table A20 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is hydrogen; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A21

[0052] Table A21 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is hydrogen; X and Y are each oxygen; n is 0;and the values of RT match those of the correspondingly numberedcompounds of Table A1.

TABLE A22

[0053] Table A22 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is hydrogen; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A23

[0054] Table A23 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is hydrogen; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A24

[0055] Table A24 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is hydrogen; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A25

[0056] Table A25 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is hydrogen; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A26

[0057] Table A26 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is hydrogen; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A27

[0058] Table A27 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is hydrogen; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A28

[0059] Table A28 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is hydrogen; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A29

[0060] Table A29 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is hydrogen; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE A30

[0061] Table A30 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is hydrogen; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE A31

[0062] Table A31 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is hydrogen; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A32

[0063] Table A32 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is hydrogen; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A33

[0064] Table A33 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is hydrogen; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A34

[0065] Table A34 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is hydrogen; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of is the correspondingly numberedcompounds of Table A1.

TABLE A35

[0066] Table A35 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is hydrogen; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A36

[0067] Table A36 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is hydrogen; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A37

[0068] Table A37 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is hydrogen; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A38

[0069] Table A38 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is hydrogen; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A39

[0070] Table A39 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo. R³ is hydrogen; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A40

[0071] Table A40 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is hydrogen; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A41

[0072] Table A41 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is hydrogen; X is oxygen; Y is NR⁷; R¹ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE A42

[0073] Table A42 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE A43

[0074] Table A43 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is hydrogen; X is oxygen; Y is NRC; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE A44

[0075] Table A44 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE A45

[0076] Table A45 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE A46

[0077] Table A46 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE A47

[0078] Table A47 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE A48

[0079] Table A48 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE A49

[0080] Table A49 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match ?5 those of thecorrespondingly numbered compounds of Table A1.

TABLE A50

[0081] Table A50 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE A51

[0082] Table A51 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A52

[0083] Table A52 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A53

[0084] Table A53 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A54

[0085] Table A54 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A55

[0086] Table A55 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A56

[0087] Table A56 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A57

[0088] Table AS7 provides 352 compounds of formula (ab) wherein R¹ isethyl; R² is fluoro; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A58

[0089] Table A58 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A59

[0090] Table A59 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A60

[0091] Table A60 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A61

[0092] Table A61 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is hydrogen; X is oxygen; Y is NR⁷; R¹ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A62

[0093] Table A62 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A63

[0094] Table A63 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is hydrogen; X is oxygen; Y is NRC; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A64

[0095] Table A64 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A65

[0096] Table A65 provides 352 compounds of formula(ab) wherein R¹ ismethyl; R² is cyano; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A66

[0097] Table A66 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ismethyr; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A67

[0098] Table A67 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A68

[0099] Table A68 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE A69

[0100] Table A69 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE A70

[0101] Table A70 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is hydrogen; X is oxygen; Y is NR⁷; R⁴ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B1

[0102] Table B1 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is methyl; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B2

[0103] Table B2 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; is R³ is methyl; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B3

[0104] Table B3 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is methyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B4

[0105] Table B4 provides 352 compounds of formula (Ia) wherein R! ismethyl, R² is bromo; R³ is methyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B5

[0106] Table B5 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is methyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B6

[0107] Table B6 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is methyl; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B7

[0108] Table B7 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is methyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B8

[0109] Table B8 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is methyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B9

[0110] Table B9 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo;

[0111] R³ is methyl; X and Y are each oxygen; n is 0; and the values ofR¹ match those of the correspondingly numbered compounds of Table A1.

TABLE B10

[0112] Table B10 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is methyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B11

[0113] Table B11 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is methyl; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B12

[0114] Table B12 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is methyl; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B13

[0115] Table B13 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is methyl; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B14

[0116] Table B 14 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is methyl; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B15

[0117] Table B15 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is methyl; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B16

[0118] Table B16 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is methyl; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B17

[0119] Table B 17 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; is R³ is methyl; X is oxygen; Y is sulphur; n is 0;apd the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B18

[0120] Table B18 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is methyl; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B19

[0121] Table B19 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is methyl; X is oxygen; Y is sulphur, n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B20

[0122] Table B20 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is methyl; X is oxygen; Y is sulphur, n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B21

[0123] Table B21 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is methyl; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B22

[0124] Table B22 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is methyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B23

[0125] Table B23 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is methyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B24

[0126] Table B24 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; Re is bromo; R³ is methyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of is the correspondingly numberedcompounds of Table A1.

TABLE B25

[0127] Table B25 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R is cyano; R³ is methyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B26

[0128] Table B26 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is methyl; X and Y are each oxygen; n is 0;and tht values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B27

[0129] Table B27 provides 352 compounds of formula (Ib) wherein R¹ isethyl; ² is fluoro;

[0130] R³ is methyl; X and Y are each oxygen; n is 0; and the values ofR⁴ match those of the correspondingly numbered compounds of Table A1.

TABLE B28

[0131] Table B28 provides 352 compounds of formula P) wherein R¹ isethyl; R² is chloro; R³ is methyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B29

[0132] Table B29 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is methyl; X and Y are each oxygen; n is 0; andthe values of R¹ match those of the correspondingly numbered compoundsof Table A1.

TABLE B30

[0133] Table B30 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is methyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B31

[0134] Table B31 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is methyl; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B32

[0135] Table B32 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is methyl; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B33

[0136] Table B33 provides 352 compounds of formula (b) wherein R¹ ismethyl; R² is chloro; R³ is methyl; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B34

[0137] Table B34 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R is bromo; R³ is methyl; X is oxygen; Y is sulphur, n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B35

[0138] Table B35 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is methyl; X is oxygen; Y is sulphur, n is 0;and the values of ⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B36

[0139] Table B36 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is methyl; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B37

[0140] Table B37 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is methyl; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B38

[0141] Table B338 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is methyl; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B39

[0142] Table B39 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is methyl; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B40

[0143] Table B40 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is methyl; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE B41

[0144] Table B41 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; Rl is hydrogen; Rl is methyl; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE B42

[0145] Table B42 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE B43

[0146] Table B43 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE B44

[0147] Table B44 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE B45

[0148] Table B45 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE B46

[0149] Table B46 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE B47

[0150] Table B47 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE B48

[0151] Table B48 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of match those of the correspondinglynwnbered compounds of Table A1.

TABLE B49

[0152] Table B49 provides 352 compounds of formula (Ib) wherein R¹ isethyl; le is bromo; R³ is methyl; X is oxygen; Y is NRl; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B50

[0153] Table B50 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B51

[0154] Table B51 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE B52

[0155] Table B52 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is methyl; X is oxygen; Y is NRC; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B53

[0156] Table B53 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B54

[0157] Table B54 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B55

[0158] Table B55 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B56

[0159] Table B56 provides 352 compounds of formula (Ib) wherein, R¹ isethyl; R² is hydrogen; R³ is methyl; X is oxygen; Y is NR⁷; R¹ ismethyl; n iso; and the values of RW match those of the correspondinglynumbered compounds of Table A1.

TABLE B57

[0160] Table B57 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B58

[0161] Table B58 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of RV match those of the correspondingly numberedcompounds of Table A1.

TABLE B59

[0162] Table B59 provides 352 compounds of formula (ab) wherein R¹ isethyl; R² is bromo; R³ is methyl; X is oxygen; Y is NRC; R¹ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B60

[0163] Table B60 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R¹ is cyano; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B61

[0164] Table B61 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE B62

[0165] Table B62 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B63

[0166] Table B63 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B64

[0167] Table B64 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B65

[0168] Table B65 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R¹ match those of the correspondingly numberedcompounds of Table A1.

TABLE B66

[0169] Table B66 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE B67

[0170] Table B67 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B68

[0171] Table B68 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B69

[0172] Table B69 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³is methyl; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE B70

[0173] Table B70 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is methyl; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C1

[0174] Table C1 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is ethyl; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C2

[0175] Table C2 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C3

[0176] Table C3 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C4

[0177] Table C4 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C5

[0178] Table C5 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C6

[0179] Table C6 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C7

[0180] Table C7 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C8

[0181] Table C8 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C9

[0182] Table C9 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C10

[0183] Table C10 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLEC11

[0184] Table C11 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is ethyl; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C12

[0185] Table C12 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is ethyl; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C13

[0186] Table C13 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is ethyl; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C14

[0187] Table C14 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is ethyl; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C15

[0188] Table C15 provides 352compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is ethyl; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof-Table A1.

TABLE C16

[0189] Table C16 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is ethyl; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C17

[0190] Table C17 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is ethyl; X is oxygen; Y is sulphur, n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C18

[0191] Table C18 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is ethyl; X is oxygen; Y is sulphur, n is 0; andthe values of RV match those of the correspondingly numbered compoundsof Table A1.

TABLE C19

[0192] Table C19 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is ethyl; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C20

[0193] Table C20 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is ethyl; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C21

[0194] Table C21 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is ethyl; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C22

[0195] Table C22 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C23

[0196] Table C23 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C24

[0197] Table C24 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C25

[0198] Table C25 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C26

[0199] Table C26 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C27

[0200] Table C27 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R¹ is fluoro; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C28

[0201] Table C28 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C29

[0202] Table C29 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C30

[0203] Table C30 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is ethyl; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C31

[0204] Table C31 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is ethyl; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds. of Table A1.

TABLE C32

[0205] Table C32 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is ethyl; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C33

[0206] Table C33 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is ethyl; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C34

[0207] Table C34 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is ethyl; X is oxygen; Y is sulphur; n is0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C35

[0208] Table C35 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is ethyl; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C36

[0209] Table C36 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is ethyl; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C37

[0210] Table C37 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R 3 is ethyl; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C38

[0211] Table C38 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is ethyl; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C39

[0212] Table C39 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R isbromo; R³ is ethyl; X is oxygen; Y is sulphur, n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C40

[0213] Table C40 provides 352 compounds of formula (b) wherein R¹ isethyl; R² is cyano; R³ is ethyl; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE C41

[0214] Table C41 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE C42

[0215] Table C42 provides 352 compounds of formula (ab) wherein R¹ ismethyl; R² is fluoro; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE C43

[0216] Table C43 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE C44

[0217] Table C44 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C45

[0218] Table C45 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R²is cyano; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLEC46

[0219] Table C46 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE C47

[0220] Table C47 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C48

[0221] Table C48 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C49

[0222] Table C49 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C50

[0223] Table C50 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is ethyl; X is oxygen; Y is NR⁷; R¹ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C51

[0224] Table C51 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE C52

[0225] Table C52 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C53

[0226] Table C53 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C54

[0227] Table C54 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C55

[0228] Table C55 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C56

[0229] Table C56 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C57

[0230] Table C57 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C58

[0231] Table C58 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C59

[0232] Table C59 provides 352 compounds of formula (b) wherein R¹ isethyl; R² is bromo; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C60

[0233] Table C60 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE-C61

[0234] Table C61 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 6; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE C62

[0235] Table C62 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C63

[0236] Table C63 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C64

[0237] Table C64 provides 3 52 compounds of formula (Ia) wherein R¹ ismethyl; R¹ is bromo; R¹ is ethyl; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C65

[0238] Table C65 provides 3 52 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C66

[0239] Table C66 provides 352 compounds of formula (Ia) wherein R¹ isethyl; le is hydrogen; le is ethyl; X is oxygen;r Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴match those of the correspondinglynumbered compounds of Table A1.

TABLE C67

[0240] Table C67 provides 3 52 compounds of formula (Ia) wherein R¹ isethyl; R¹ is fluoro; R¹ is ethyl; is oxygen; Y is NRC; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C68

[0241] Table C68 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is ethyl; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of le match those of the correspondingly numberedcompounds of Table A1.

TABLE C69

[0242] Table C69 provides 3 52 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³is ethyl; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE C70

[0243] Table C70 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³is ethyl; X is oxygen; Y is NW⁷; R⁷ is methyl; nis 0;, and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D1

[0244] Table D1 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D2

[0245] Table D2 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D3

[0246] Table D3 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D4

[0247] Table D4 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D5

[0248] Table D5 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D6

[0249] Table D6 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is0;, and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D7

[0250] Table D7 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D8

[0251] Table D8 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D9

[0252] Table D9 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D10

[0253] Table D10 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLED11

[0254] Table D11 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D12

[0255] Table D12 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is is fluoro; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D13

[0256] Table D13 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D14

[0257] Table D14 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D15

[0258] Table DI5 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; W is cyano; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D16

[0259] Table D16 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D17

[0260] Table D17 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D18

[0261] Table Dl g provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D19

[0262] Table D19 provides 352 compounds of formula (a) wherein R¹ isethyl; R² is bromo; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D20

[0263] Table D20 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D21

[0264] Table D21 provides 352 compounds of formula (b) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is(Y, and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D22

[0265] Table D22 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D23

[0266] Table D23 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D24

[0267] Table D24 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D25

[0268] Table D25 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D26

[0269] Table D26 provides 352 compounds of formula (b) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D27

[0270] Table D27 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D28

[0271] Table D28 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D29

[0272] Table D29 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D30

[0273] Table D30 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D31

[0274] Table D31 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D32

[0275] Table D32 provides 352 compounds of formula (Ib) wherein RX ismethyl; R² is fluoro; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D33

[0276] Table D33 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D34

[0277] Table D34 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D35

[0278] Table D35 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE1 D36

[0279] Table D36 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur, n is0, and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D37

[0280] Table D37 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D38

[0281] Table D38 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CH₂CH3; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D39

[0282] Table D39 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D40

[0283] Table D40 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CH₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE D41

[0284] Table D41 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE D42

[0285] Table D42 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CH,.CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE D43

[0286] Table D43 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂C₂H; X is oxygen Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of IV match those of thecorrespondingly numbered compounds of Table A1.

[0287] Table D44 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; W is bromo; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of match those of the correspondinglynumbered compounds of Table A1.

TABLE D45

[0288] Table D45 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE D46

[0289] Table D46 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE D47

[0290] Table D47 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE D48

[0291] Table D48 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE D49

[0292] Table D49 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match 1s those of thecorrespondingly numbered compounds of Table A1.

TABLE D50

[0293] Table D50 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE D51

[0294] Table D51 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE D52

[0295] Table D52 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE D53

[0296] Table D53 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE D54

[0297] Table D54 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R¹ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE D55

[0298] Table D55 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE D56

[0299] Table D56 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE D57

[0300] Table D57 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE D58

[0301] Table D58 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro;

[0302] R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ is methyl; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE D59

[0303] Table D59 provides 352 compounds of formula (Ib) wherein R! isethyl; R² is bromo;

[0304] R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ is methyl; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE D60

[0305] Table D60 provides 352 compounds of formula (b) wherein R¹ isethyl; l² is cyano;

[0306] R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ is methyl; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE D61

[0307] Table D61 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CH₂CH₃; X is oxygen; Y is NRC; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE D62

[0308] Table D62 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE D63

[0309] Table D63 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R¹ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE D64

[0310] Table D64 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; k⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE D65

[0311] Table D65 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CH₂CH₃; X is oxygen; Y is NRC; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE D66

[0312] Table D66 provides 352 compoundsof formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE D67

[0313] Table D67 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R¹ match those of the correspondinglynumbered compounds of Table A1.

TABLE D68

[0314] Table D68 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE D69

[0315] Table D69 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE D70

[0316] Table D70 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLEE1

[0317] Table E1 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CH—CH₂; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E2

[0318] Table E2 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E3

[0319] Table E3 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E4

[0320] Table E4 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH2CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E5

[0321] Table ES provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E6

[0322] Table E6 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E7

[0323] Table E7 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E8

[0324] Table E8 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂CH—CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E9

[0325] Table E9 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E10

[0326] Table E10 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E11

[0327] Table E11 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E12

[0328] Table E12 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E13

[0329] Table E13 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E14

[0330] Table E14 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E15

[0331] Table E15 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E16

[0332] Table E16 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E17

[0333] Table E17 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E18

[0334] Table E18 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E19

[0335] Table E19 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E20

[0336] Table E20 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂CH═CH₂,; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E21

[0337] Table E21 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E22

[0338] Table E22 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E23

[0339] Table E23 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E24

[0340] Table E24 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CH—CH₂; X and Y are each oxygen; n is 0;and the values of R¹ match those of the correspondingly numberedcompounds of Table A1.

[0341] Table E25 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E26

[0342] Table E26 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E27

[0343] Table E27 provides 352 compounds of formula (Ib) wherein R¹ isethyl; -R² is fluoro; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E28

[0344] Table E28 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E29

[0345] Table E29 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E30

[0346] Table E30 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CH═CH₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E31

[0347] Table E31 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E32

[0348] Table E32 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E33

[0349] Table E33 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E34

[0350] Table E34 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E35

[0351] Table E35 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E36

[0352] Table E36 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E37

[0353] Table E37 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E38

[0354] Table E38 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E39

[0355] Table E39 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE E40

[0356] Table E40 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CH═CH₂; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE 41

[0357] Table E41 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R²is hydrogen; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE E42

[0358] Table E42 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE E43

[0359] Table E43 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE E44

[0360] Table E44 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE E45

[0361] Table E45 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE E46

[0362] Table E46 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE F47

[0363] Table E47 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE E48

[0364] Table E48 provides 352 compounds of formula (Ib) wherein R¹is-ethyl; R² is chloro; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE 49

[0365] Table E49 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; ⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE E50

[0366] Table E50 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CH═CH₂; X is oxygen; Y is NR!; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE E51

[0367] Table E51 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E52

[0368] Table E52 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E53

[0369] Table E53 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E54

[0370] Table E54 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E55

[0371] Table E55 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E56

[0372] Table E56 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E57

[0373] Table E57 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro;

[0374] R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ is methyl; n is 0; andthe values of-R match those of the correspondingly numbered compounds ofTable A1.

TABLE E58

[0375] Table E58 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E59

[0376] Table E59 provides 352 compounds of formula (ab) wherein R¹ isethyl; R² is bromo; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E60

[0377] Table E60 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E61

[0378] Table E61 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E62

[0379] Table E62 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E63

[0380] Table E63 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E64

[0381] Table E64 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E65

[0382] Table E65 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E66

[0383] Table E66 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of RW match those of the correspondinglynumbered compounds of Table A1.

TABLE E67

[0384] Table E67 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E68

[0385] Table E68 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E69

[0386] Table E69 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE E70

[0387] Table E70 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂CH═CH₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match hose of the correspondinglynumbered compounds of Table A1.

TABLE F1

[0388] Table F1 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂C.CH; X and Y are each oxygen, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F2

[0389] Table F2 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂C.CH; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F3

[0390] Table F3 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂C.CH; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F4

[0391] Table F4 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂C.CH; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE F5

[0392] Table F5 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂C.CH; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE F6

[0393] Table F6 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂C.CH; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F7

[0394] Table F7 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂C.CH; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE F8

[0395] Table F8 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; is CH₂C.CH; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE F9

[0396] Table F9 provides 352 compounds of formula (Ia) wherein RV isethyl; R² is chloro; R³ is CH₂C.CH; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE F10

[0397] Table F10 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂C.CH; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE F11

[0398] Table F11 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂C.CH; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F12

[0399] Table F12 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂C.CH; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F13

[0400] Table F13 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂C.CH; X is oxygen; Y is sulphur, n is 0;and the values of Ra match those of the correspondingly numberedcompounds of Table A1.

TABLE F14

[0401] Table F14 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂C.CH; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F15

[0402] Table F15 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂C.CH; X is oxygen; Y is sulphur, n is 0,and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F16

[0403] Table F16 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂C.CH; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F17

[0404] Table F17 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂C.CH; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F18

[0405] Table F18 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂C.CH; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F19

[0406] Table F19 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂C.CH; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F20

[0407] Table F20 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂C.CH; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F21

[0408] Table F21 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂C.CH; X and Y are each oxygen; n is 0;and the values of ⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F22

[0409] Table F22 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is is fluoro; R³ is CH₂C.CH; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F23

[0410] Table F23 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂C.CH; X and Y are each oxygen, n is 0;and the values of R⁴ match-those of the correspondingly numberedcompounds of Table A1.

TABLE F24

[0411] Table F24 provides 352 compounds formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂C.CH; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE F25

[0412] Table F25 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂C.CH; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE F26

[0413] Table F26 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂C.CH; X and Y are each oxygen; n is 0;and the values of R¹ match those of the correspondingly numberedcompounds of Table A1.

TABLE F27

[0414] Table F27 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂C.CH; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE F28

[0415] Table F28 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂C.CH; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE F29

[0416] Table F29 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂C.CH; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE F30

[0417] Table F30 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂C.CH; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE F31

[0418] Table F31 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂C.CH; X is oxygen; Y is sulphur n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F32

[0419] Table F32 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂C.CH; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F33

[0420] Table F33 provides 352 compounds of formula (b) wherein R¹ ismethyl; R² is chloro; R³ is CH₂C.CH; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F34

[0421] Table F34 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂C.CH; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F35

[0422] Table F35 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂C.CH; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F36

[0423] Table F36 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂C.CH; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F37

[0424] Table F37 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂C.CH; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F38

[0425] Table F38 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂C.CH; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F39

[0426] Table F39 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂C.CH; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F40

[0427] Table F40 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂C.CH; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F41

[0428] Table F41 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE F42

[0429] Table F42 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE F43

[0430] Table F43 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE F44

[0431] Table F44 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE F45

[0432] Table F45 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; ²is cyano; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F46

[0433] Table F46 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE F47

[0434] Table F47 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE F48

[0435] Table F48 provides 352 compounds of formula (Ib) wherein R¹ isethyl, R² is chloro; R³ is CH.C.CH; Xis oxygen; Y is NR⁷; EC ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE F49

[0436] Table F49 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R¹ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE F50

[0437] Table F50 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano;

[0438] R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ is hydrogen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE F51

[0439] Table F51 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE F52

[0440] Table F52 provides 352 compounds of formula (Ib) wherein R! ismethyl; R² is fluoro; R³ is CH₂C.CH; X is oxygen; Y is NR¹; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE F53

[0441] Table F53 provides 352 compounds formula (Ib) wherein R¹ ismethyl, R² is chloro; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R¹ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynuinbered compounds of Table A1.

TABLE F54

[0442] Table F54 provides 352 compounds of formula (Ib) wherein R¹ ismethyl, R² is bromo; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F55

[0443] Table F55 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F56

[0444] Table F56 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE F57

[0445] Table F57 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F58

[0446] Table F58 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂C.CH; X isoxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F59

[0447] Table F59 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F60

[0448] Table F60 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂C.CH; X is oxygen; Y is NRC; R⁷ is methyl;n is 0; and Mhe values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F61

[0449] Table F61 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; V ismiethyl, n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE F62

[0450] Table F62 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE F63

[0451] Table F63 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂C.CH; X is oxygen, Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE F64

[0452] Table F64 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F65

[0453] Table F65 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F66

[0454] Table F66 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE F67

[0455] Table F67 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F68

[0456] Table F68 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the valuesofR4 match hose of the correspondingly nunberedcompounds of Table A1.

TABLE F69

[0457] Table F69 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE F70

[0458] Table F70 provides 352 compounds of formula (Ia) wherein R¹ isethyl;R2 is cyano; R³ is CH₂C.CH; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G1

[0459] Table G1 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CN; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G2

[0460] Table G2 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R? is fluoro; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G3

[0461] Table G3 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G4

[0462] Table G4 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R match those of the correspondingly numbered compounds ofTable A1.

TABLE G5

[0463] Table G5 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G6

[0464] Table G6 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of ie match those of the correspondingly numbered compoundsof Table A1.

TABLE G7

[0465] Table G7 provides 352 compounds of formula (Ia) wherein R¹ isethyl; ² is fluoro; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G8

[0466] Table G8 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G9

[0467] Table G9 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo. R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G10

[0468] Table G10 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G11

[0469] Table G11 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CN; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G12

[0470] Table G12 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CN; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G13

[0471] Table G13 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CN; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G14

[0472] Table G14 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CN; X is oxygen; Y is sulphur, n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G15

[0473] Table G15 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CN; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G16

[0474] Table G16 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CN; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G17

[0475] Table G17 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CN; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G18

[0476] Table G18 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂CN; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G19

[0477] Table G19 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo;

[0478] R³ is CH₂CN; X is oxygen; Y is sulphur, n is 0; and the values of⁴ match those of the correspondingly numbered compounds of Table A1.

TABLE G20

[0479] Table G20 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R? is cyano;

[0480] R³ is CH₂CN; X is oxygen; Y is sulphur, n is 0; and the values ofR⁴ match those of the correspondingly numbered compounds of Table A1.

TABLE G21

[0481] Table G21 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CN; X and Y are each oxygen; n is 0;and the-values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G22

[0482] Table G22 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G23

[0483] Table G23 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G24

[0484] Table G24 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G25

[0485] Table G25 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of RV match those of the correspondingly numbered compoundsof Table A1.

TABLE G26

[0486] Table G26 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G27

[0487] Table G27 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G28

[0488] Table G28 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compound ofTable A1.

TABLE G29

[0489] Table G29 provides 352 compoundsofformula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G30

[0490] Table G30 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CN; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G31

[0491] Table G3 1 provides 352 compounds of formula (1b) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CN; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G32

[0492] Table G32 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CN; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G33

[0493] Table G33 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CN; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G34

[0494] Table G34 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CN; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G=35

[0495] Table G35 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CN; X is oxygen; Y is sulphur, n is 0; andthe values of R⁴=match those of the correspondingly numbered compoundsof Table A1.

TABLE G33

[0496] Table G36 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CN; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G37

[0497] Table G37 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CN; X is oxygen; Y is sulphur, n is 0; andthe values of Rl match those of the correspondingly numbered compoundsof Table A1.

TABLE G38

[0498] Table G38 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CN; X is oxygen; Y is sulphur, n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G39

[0499] Table G39 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CN; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G40

[0500] Table G40 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CN; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE G41

[0501] Table G41 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE G42

[0502] Table G42 provides 352 compounds of formula (ab) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE G43

[0503] Table G43 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CN;X is oxygen; Y is NR⁷;R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G44

[0504] Table G44 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CN; X is oxygen; Y is NR⁷;R⁷ is hydrogen;n is 0, and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G45

[0505] Table G45 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G46

[0506] Table G46 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE G47

[0507] Table G47 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G48

[0508] Table G48 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G49

[0509] Table G49 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G50

[0510] Table G50 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is hydrogen;nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G51

[0511] Table G51 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE G52

[0512] Table G52 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G53

[0513] Table G53 provides 352 compounds of formula (b) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G54

[0514] Table G54 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G55

[0515] Table G55 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CN; X is oxygen; Y is NR⁷; R¹ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G56

[0516] Table 056 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G57

[0517] Table G57 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G58

[0518] Table G58 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G59

[0519] Table G59 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G60

[0520] Table G60 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G61

[0521] Table G61 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE G62

[0522] Table G62 provides 352 compounds of formula (Oa) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G63

[0523] Table G63 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G64

[0524] Table G64 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G65

[0525] Table G65 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CN; X is oxygen; Y is NRI; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G66

[0526] Table G66 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G67

[0527] Table G67 provides 352 compounds of formula (Ia) wherein R¹ isethyl, R² is fluoro; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G68

[0528] Table G68 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G69

[0529] Table G69 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE G70

[0530] Table G70 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂CN; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H1

[0531] Table H1 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CF₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H2

[0532] Table H2 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CF₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE H3

[0533] Table H3 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CF₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE H4

[0534] Table H4 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CF₃; X and Y are each oxygen; n is 0; andthe values of match those of the correspondingly numbered compounds ofTable A1.

TABLE H5

[0535] Table H5 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CF₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE H6

[0536] Table H6 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CF₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H7

[0537] Table H7 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CF₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE H8

[0538] Table H8 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂CF₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE H9

[0539] Table H9 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂CF₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE H10

[0540] Table H10 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂CF₃; X and Y are each oxygen; n is 0; andthe-values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE H11

[0541] Table H11 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CF₃; X is oxygen; Y is sulphur, n is 0,and the values of R¹ match those of the correspondingly numberedcompounds of Table A1.

TABLE H12

[0542] Table H12 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CF₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H13

[0543] Table H13 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CF.; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H14

[0544] Table H14 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CF₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H15

[0545] Table H15 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CF₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H16

[0546] Table H16 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CF₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H17

[0547] Table H17 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; is R³ is CH₂CF₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H18

[0548] Table H18 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro;

[0549] R³ is CH₂CF₃; X is oxygen; Y is sulphur, n is 0; and the valuesof RT match those of the correspondingly numbered compounds of Table A1.

TABLE H19

[0550] Table H19 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂CF₃; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE H20

[0551] Table H20 provides 352 compounds of formula (Ia) wherein R! isethyl; R² is cyano;

[0552] R³ is CH2CF3; X is oxygen; Y is sulphur, n is 0; and the valuesof R⁴ match those of the correspondingly numbered compounds of Table A1.

TABLE H21

[0553] Table H21 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CF₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H22

[0554] Table H22 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CF₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE H23

[0555] Table H23 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R¹ is chloro; R³ is CH₂CF₃; X and Y are each oxygen; n is 0; andthe values of RV match those of the correspondingly numbered compoundsof Table A1.

TABLE H24

[0556] Table H24 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CF₃; X and Y are each oxygen; n is 0; andthe values of ⁴ match those of the correspondingly numbered compounds ofTable A1.

TABLE H25

[0557] Table H125 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CF₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1,

TABLE H26

[0558] Table H26 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CF₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H27

[0559] Table H27 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CF₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE 1128

[0560] Table H28 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CF₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE H29

[0561] Table H29 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CF₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE H30

[0562] Table H30 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CF₃; X and Y are each oxygen; n is 0, andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE H31

[0563] Table H31 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CF₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H32

[0564] Table H32 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CF₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H33

[0565] Table H33 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CF₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H34

[0566] Table H34 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CF₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H35

[0567] Table H35 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; le is CH₂CF₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H36

[0568] Table H36 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CF₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H37

[0569] Table H37 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CF₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H38

[0570] Table H38 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CF₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H39

[0571] Table H39 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CF₃; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE H40

[0572] Table H40 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CF₃; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE H41

[0573] Table H41 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE H42

[0574] Table H42 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE H43

[0575] Table H43 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE H44

[0576] Table H44 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE H45

[0577] Table H45 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE H46

[0578] Table H46 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE H47

[0579] Table H47 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE H48

[0580] Table H48 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE H49

[0581] Table H49 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H50

[0582] Table H50 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H51

[0583] Table H51 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE H52

[0584] Table H52 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H53

[0585] Table H53 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H54

[0586] Table H54 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H55

[0587] Table H55 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondinglynumbered-compounds of Table A1.

TABLE H56

[0588] Table H56 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE H57

[0589] Table H57 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H58

[0590] Table H58 provides 352 compounds, of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H59

[0591] Table H59 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CF3; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H60

[0592] Table H60 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H61

[0593] Table H61 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE H62

[0594] Table H62 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H63

[0595] Table H63 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R¹ match those of the correspondinglynumbered-compounds of Table A1.

TABLE H64

[0596] Table H64 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R¹ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H65

[0597] Table H65 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H66

[0598] Table H66 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE H67

[0599] Table H67 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H68

[0600] Table H68 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H69

[0601] Table H69 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂CF₃; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE H70

[0602] Table H70 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂CF₃; X is oxygen; Y is NRi; R⁷ is methyl;nis O;and the values t fiR4 match those of the correspondingly numberedcompounds of Table A1.

TABLE I1

[0603] Table I1 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CO₂CH₃; X and Y are each oxygen; nis 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I2

[0604] Table I2 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I3

[0605] Table I3 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I4

[0606] Table I4 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I5

[0607] Table I5 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE 16

[0608] Table 16 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen;

[0609] R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0; and the valuesof R⁴ match those of the correspondingly numbered compounds of Table A1.

TABLE I7

[0610] Table I7 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE 18

[0611] Table 18 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I9

[0612] Table I9 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R¹ match those of the correspondingly numberedcompounds of Table A1.

TABLE I10

[0613] Table I10 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano;

[0614] R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0; and the valuesof R⁴ match those of the correspondingly numbered compounds of Table A1.

TABLE I11

[0615] Table I11 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I12

[0616] Table I12 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CHCO₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I13

[0617] Table I13 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I14

[0618] Table I14-provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I15

[0619] Table I15 provides 352compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I16

[0620] Table I16 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I17

[0621] Table I17 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I18

[0622] Table I18 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I19

[0623] Table I19 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I20

[0624] Table I20 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I21

[0625] Table I21 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I22

[0626] Table I22 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I23

[0627] Table I23 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompound of Table A1.

TABLE I24

[0628] Table I24 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I25

[0629] Table I25 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I26

[0630] Table I26 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I27

[0631] Table I27 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I28

[0632] Table I28 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R match those of the correspondingly numberedcompounds of Table A1.

TABLE I29

[0633] Table I29 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I30

[0634] Table I30 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CO₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I31

[0635] Table I31 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur, n is0, and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I32

[0636] Table I32 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I33

[0637] Table I33 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I34

[0638] Table I34 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I35

[0639] Table I35 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I36

[0640] Table I36 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I37

[0641] Table I37 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I38

[0642] Table I38 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I39

[0643] Table I39 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur; n is 0,and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I40

[0644] Table I40 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CO₂CH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE I41

[0645] Table I41 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R¹ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE I42

[0646] Table I42 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE I43

[0647] Table I43 provides 352 compounds of formula (b) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE I44

[0648] Table I44 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE I45

[0649] Table I45 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE I46

[0650] Table I46 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE I47

[0651] Table I47 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE I48

[0652] Table I48 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE I49

[0653] Table I49 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE I50

[0654] Table I50 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE I51

[0655] Table I51 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I52

[0656] Table I52 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I53

[0657] Table I53 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I54

[0658] Table I54 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CO₂CH_(3;) X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I55

[0659] Table I55 provides 352 compounds of formula (Ib) wherein R⁷ ismethyl; R² is cyano; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I56

[0660] Table I56 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I57

[0661] Table I57 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁴ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I58

[0662] Table I58 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I59

[0663] Table I59 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I60

[0664] Table I60 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I61

[0665] Table I61 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is, CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I62

[0666] Table I62 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂CO₂CH_(3;) X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I63

[0667] Table I63 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R¹ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I64

[0668] Table I64 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I65

[0669] Table I65 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I66

[0670] Table I66 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I67

[0671] Table I67 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I68

[0672] Table I68 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; k⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE I69

[0673] Table I69 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of RV match those of the correspondinglynumbered compounds of Table A1.

TABLE I70

[0674] Table I70 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂CO₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE J1

[0675] Table J1 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂Ph; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J2

[0676] Table J2 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J3

[0677] Table J3 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J4

[0678] Table J4 provides 352 compounds of formula (Ia) wherein R¹ ismethyl, R² is bromo; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J5

[0679] Table J5 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J6

[0680] Table J6 provides 352 compounds of formula (Ia) wherein R isethyl; R² is hydrogen; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J7

[0681] Table J7 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; RV is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J8

[0682] Table J8 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J9

[0683] Table J9 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J10

[0684] Table J10 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J11

[0685] Table J11 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂Ph; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J12

[0686] Table J12 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂Ph; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J13

[0687] Table J13 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH2Ph; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J14

[0688] Table J14 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂Ph; X is oxygen; Y is sulphur, n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J15

[0689] Table J15 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂Ph; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J16

[0690] Table J16 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R¹ is hydrogen; R³ is CH₂Ph; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J17

[0691] Table J17 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂Ph; X is oxygen; Y is sulphur, n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J18

[0692] Table 318 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂Ph; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J19

[0693] Table J19 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂Ph; X is oxygen; Y is sulphur, n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J20

[0694] Table J20 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂Ph; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE 21

[0695] Table J21 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂Ph; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J22

[0696] Table J22 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J23

[0697] Table J23 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J24

[0698] Table J24 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J25

[0699] Table J25 provides 352 compounds of formula (Tb) wherein R¹ ismethyl; R² is cyano; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J26

[0700] Table J26 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J27

[0701] Table J27 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J28

[0702] Table J28 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J29

[0703] Table J29 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J30

[0704] Table J30 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂Ph; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J31

[0705] Table J31 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂Ph; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J32

[0706] Table J32 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂Ph; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J33

[0707] Table J33 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂Ph; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J34

[0708] Table J34 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂Ph; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J35

[0709] Table J35 provides 352 compounds of formula (ab) wherein R¹ ismethyl; R² is cyan; R³ is CH₂Ph; X is oxygen; Y is sulphur, n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

[0710] TABLE J36

[0711] Table J36 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂Ph; X is oxygen; Y is sulphur, n is0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J37

[0712] Table 337 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂Ph; X is oxygen; Y is sulphur, n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J38

[0713] Table J38 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂Ph; X is oxygen; Y is sulphur, n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J39

[0714] Table J39 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂Ph; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J40

[0715] Table J40 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂Ph; X is oxygen; Y is sulphur; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE J41

[0716] Table J41 provides 352 compounds of formula (ab) wherein R¹ ismethyl; R² is a hydrogen; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE J42

[0717] Table J42 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is is fluoro; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE J43

[0718] Table J43 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ ishydrogen;-n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE J44

[0719] Table J44 provides 352 compounds of formula (Ib) wherein R¹ ismethyl, R² is bromo; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J45

[0720] Table J45 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of RV match those of the correspondingly numberedcompounds of Table A1.

TABLE J46

[0721] Table J46 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE J47

[0722] Table J47 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J48

[0723] Table J48 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J49

[0724] Table J49 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J50

[0725] Table J50 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is hydrogen;n is 0; and the values of ⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J51

[0726] Table J51 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R¹ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE J52

[0727] Table J52 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R¹ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J53

[0728] Table J53 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the corresondingly numberedcompounds of Table A1.

TABLE J54

[0729] Table J54 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J55

[0730] Table J55 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J56

[0731] Table J56 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE 357

[0732] Table J57 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J58

[0733] Table J58 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J59

[0734] Table J59 provides 352 compounds of formula (Ib) wherein isethyl; R² is bromo; R³ is CH2Ph; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J60

[0735] Table J60 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R³ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J61

[0736] Table J61 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match tose of the correspondinglynumbered compounds of Table A1.

TABLE J62

[0737] Table J62 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R¹ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J63

[0738] Table J63 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J64

[0739] Table J64 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH2Ph; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of ⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J65

[0740] Table J65 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of othe correspondingly numberedcompounds of Table A1.

TABLE J66

[0741] Table J66 provides 352 compounds of formula (Ia) wherein Rl isethyl; R² is hydrogen; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J67

[0742] Table J67 provides 352 compounds of formula (Ia) wherein R¹ isethyl; l² is fluoro; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J68

[0743] Table J68 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH2Ph; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J69

[0744] Table J69 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂Ph; X is oxygen; Y is NR⁷; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE J70

[0745] Table J70 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂Ph; X is oxygen; Y is NRC; R⁷ is methyl; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K1

[0746] Table K1 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K2

[0747] Table K2 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; is R³ is CH₂OCH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K3

[0748] Table K3 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K4

[0749] Table K4 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE K5

[0750] Table K5 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE K6

[0751] Table K6 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K7

[0752] Table K7 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE K8

[0753] Table K8 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE K9

[0754] Table K9 provides 352 compounds of formula (Ia) wherein RV isethyl; R² is bromo; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE K10

[0755] Table K10 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE K11

[0756] Table K11 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂0CH₃; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K12

[0757] Table K12 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K13

[0758] Table K13 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K14

[0759] Table K14 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K15

[0760] Table K15 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K16

[0761] Table K16 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K17

[0762] Table K17 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂0CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K18

[0763] Table K18 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K19

[0764] Table K19 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K20

[0765] Table K20 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K21

[0766] Table K21 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K22

[0767] Table K22 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K23

[0768] Table K23 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K24

[0769] Table K24 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE K25

[0770] Table K25 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₃; X and Y are each oxygen, n is 0,;and the values ofV match those of the correspondingly numbered compoundsof Table A1.

TABLE K26

[0771] Table K26 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH, X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K27

[0772] Table K27 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CHO₂CH3; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE K28

[0773] Table K28 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE K29

[0774] Table K29 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE K30

[0775] Table K30 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₃; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE K131

[0776] Table K3 1 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₃; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K32

[0777] Table K32 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K33

[0778] Table K33 provides 352 compounds of formula (Ib) wherein R¹ ismethyl, R² is chloro; R³ is CH₂OCH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K34

[0779] Table K34 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂0CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE: K35

[0780] Table K35 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K36

[0781] Table K36 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K37

[0782] Table K37 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K38

[0783] Table K38 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH20CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K39

[0784] Table K39 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K40

[0785] Table K40 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂0CH₃; X is oxygen; Y is sulphur, n is 0;and the values of le match those of the correspondingly numberedcompounds of Table A1.

TABLE K41

[0786] Table K41 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE K42

[0787] Table K42 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R¹ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE K43

[0788] Table K43 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE K44

[0789] Table K44 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE K45

[0790] Table K45 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE K46

[0791] Table K46 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE K47

[0792] Table K47 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; is R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE K48

[0793] Table K48 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁴ ishydrogen; n is 0; and the values of R match those of the correspondinglynumbered compounds of Table A1.

TABLE K49

[0794] Table K49 provides 352 compounds of formula (Ib) Wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE K50

[0795] Table K50 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE K51

[0796] Table K51 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE K52

[0797] Table K52 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE K53

[0798] Table K53 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE K54

[0799] Table K54 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂0CH₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K55

[0800] Table K55 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

[0801] Table K56 provides 352,compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl n is; and the values R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE K57

[0802] Table K57 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K58

[0803] Table K58 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K59

[0804] Table K59 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K60

[0805] Table K60 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K61

[0806] Table K61 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE K62

[0807] Table K62 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE K63

[0808] Table K63 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumber compounds of Table A1.

TABLE K64

[0809] Table K64 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K65

[0810] Table K65 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ is methyl,n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K66

[0811] Table K66 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE K67

[0812] Table K67 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K68

[0813] Table K68 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K69

[0814] Table K69 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE K70

[0815] Table K70 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L1

[0816] Table L1 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L2

[0817] Table L2 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro, R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L3

[0818] Table L3 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L4

[0819] Table L4 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₂CH3; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L5

[0820] Table L5 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L6

[0821] Table L6 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L7

[0822] Table L7 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L8

[0823] Table L8 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L9

[0824] Table L9 provides 352 compounds of formula (Ia) wherein R¹ isethyl R² is bromo; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L10

[0825] Table L10 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L11

[0826] Table L11 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L12

[0827] Table L12 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L13

[0828] Table L13 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur; n is0; and the values of R¹ match those of the correspondingly numberedcompounds of Table A1.

TABLE L14

[0829] Table L14 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L15

[0830] Table L15 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L16.

[0831] Table L16 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L17

[0832] Table L17 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L18

[0833] Table L18 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur, n is0; and the values of RV match those of the correspondingly numberedcompounds of Table A1.

TABLE L19

[0834] Table L19 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L20

[0835] Table L20 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L21

[0836] Table L21 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L22

[0837] Table L22 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L23

[0838] Table L23 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH2OCH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L24

[0839] Table L24 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L25

[0840] Table L25 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L26

[0841] Table L26 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L27

[0842] Table L27 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L28

[0843] Table L28 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L29

[0844] Table L29 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L30

[0845] Table L30 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₂CH₃; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L31

[0846] Table L31 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur, nis 0, and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L32

[0847] Table L32 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L33

[0848] Table L33 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L34

[0849] Table L34 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L35

[0850] Table L35 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L36

[0851] Table L36 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L37

[0852] Table L37 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L38

[0853] Table L38 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur, n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L39

[0854] Table L39 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L40

[0855] Table L40 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₂CH₃; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE L41

[0856] Table L41 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE L42

[0857] Table L42 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R¹ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE L43

[0858] Table L43 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE L44

[0859] Table L44 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE LA5

[0860] Table L45 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered-compounds of Table A1.

TABLE L46

[0861] Table L46 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₂,CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE L47

[0862] Table L47 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE L48

[0863] Table L48 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂0CH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE L49

[0864] Table L49 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE L50

[0865] Table L50 provides 352 compounds of formula (b) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE L51

[0866] Table L51 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L52

[0867] Table L52 provides 352 compounds of formula (b) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L53

[0868] Table L53 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L54

[0869] Table L54 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L55

[0870] Table L55 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L56

[0871] Table L56 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R¹ is hydrogen; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L57

[0872] Table L57 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L58

[0873] Table L58 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₂CH3; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L59

[0874] Table L59 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁴ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L60

[0875] Table L60 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R match those of the correspondinglynumbered compounds of Table A1.

TABLE L61

[0876] Table L61 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L62

[0877] Table L62 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L63

[0878] Table L63 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L64

[0879] Table L64 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L65

[0880] Table L65 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L66

[0881] Table L66 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L67

[0882] Table L67 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L68

[0883] Table L68 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L69

[0884] Table L69 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE L70

[0885] Table L70 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₂CH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE M1

[0886] Table M1 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M2

[0887] Table M2 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M3

[0888] Table M3 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M4

[0889] Table M4 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M5

[0890] Table M5 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M6

[0891] Table M6 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M7

[0892] Table M7 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M8

[0893] Table M8 provides 352 compounds of formula (Ia) wherein R isethyl; R² is chloro; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M9

[0894] Table M9 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M10

[0895] Table M10 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M11

[0896] Table M11 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur,n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M12

[0897] Table M12 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur, nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M13

[0898] Table M13 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur, nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M14

[0899] Table M14 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur, nis 0; and the values of RX match those of the correspondingly numberedcompounds of Table A1.

TABLE M15

[0900] Table M15 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur, nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M16

[0901] Table M16 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M17

[0902] Table M17 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M18

[0903] Table M18 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₂CH₂0CH₃; X is oxygen; Y is sulphur; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M19

[0904] Table M19 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M20

[0905] Table M20 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M21

[0906] Table M21 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R²is hydrogen; R³ is CH₂.OCH₂CH₂OCH₃; X and Y are each oxygen, nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M22

[0907] Table M22 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M23

[0908] Table M23 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M24

[0909] Table M24 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M25

[0910] Table M25 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M26

[0911] Table M26 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M27

[0912] Table M27 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M28

[0913] Table M28 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; a R³ is CH₂OCH₂CH₂0CH₃; X and Y are each oxygen; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M29

[0914] Table M29 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M30

[0915] Table M30 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₂CH₂OCH₃; X and Y are each oxygen; n is0; and the values of RV match those of the correspondingly numberedcompounds of Table A1.

TABLE M31

[0916] Table M31 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur;n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M32

[0917] Table M32 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur, nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M33

[0918] Table M33 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M34

[0919] Table M34 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur, nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M35

[0920] Table M35 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M36

[0921] Table M36 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur,n is 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M37

[0922] Table M37 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur, nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M38

[0923] Table M38 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₂CH₂0CH₃; X is oxygen; Y is sulphur, nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M39

[0924] Table M39 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M40

[0925] Table M40 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is sulphur; nis 0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE M41

[0926] Table M41 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R¹is hydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE M42

[0927] Table M42 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R¹ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE M43

[0928] Table M43 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R³ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE M44

[0929] Table M44 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE M45

[0930] Table M45 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE M46

[0931] Table M46 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷is hydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE M47

[0932] Table M47 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE M48

[0933] Table M48 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE M49

[0934] Table M49 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE M50

[0935] Table M50 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE M51

[0936] Table M51 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷is methyl; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE M52

[0937] Table M52 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE M53

[0938] Table M53 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE M54

[0939] Table M54 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the-values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE M55

[0940] Table M55 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE M56

[0941] Table M56 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷is methyl; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE M57

[0942] Table M57 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE M58

[0943] Table M58 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE M59

[0944] Table M59 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE M60

[0945] Table M60 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE M61

[0946] Table M61 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R¹is methyl; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE M62

[0947] Table M62 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R match those of the correspondinglynumbered compounds of Table A1.

TABLE M63

[0948] Table M63 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE M64

[0949] Table M64 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE M65

[0950] Table M65 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE M66

[0951] Table M66 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷is methyl; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE M67

[0952] Table M67 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE M68

[0953] Table M68 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE M69

[0954] Table M69 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE M70

[0955] Table M70 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH₂OCH₂CH₂OCH₃; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE N1

[0956] Table N1 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is hydrogen; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N2

[0957] Table N2-provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N3

[0958] Table N3 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N4

[0959] Table N4 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N5

[0960] Table N5 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N6

[0961] Table N6 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N7

[0962] Table N7 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N8

[0963] Table N8 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; is CH(CH₃)₂; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE N9

[0964] Table N9 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE N10

[0965] Table N10 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE N11

[0966] Table N11 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R²is hydrogen; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur, n is0; and values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N12

[0967] Table N12 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N13

[0968] Table N13 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH(CH₃)2; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N14

[0969] Table N14 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N15

[0970] Table N15 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is cyano; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N16

[0971] Table N16 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is hydrogen; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N17

[0972] Table N17 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is fluoro; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N18

[0973] Table N18 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is chloro; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N19

[0974] Table N19 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is bromo; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N20

[0975] Table N20 provides 352 compounds of formula (Ia) wherein R¹ isethyl; R² is cyano; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N21

[0976] Table N21 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N22

[0977] Table N22 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N23

[0978] Table N23 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N24

[0979] Table N24 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0;and the values of R¹ match those of the correspondingly numberedcompounds of Table A1.

TABLE N25

[0980] Table N25 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N26

[0981] Table N26 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N27

[0982] Table N27 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N28

[0983] Table N28 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N29

[0984] Table N29 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE N30

[0985] Table N30 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH(CH₃)₂; X and Y are each oxygen; n is 0; andthe values of R⁴ match those of the correspondingly numbered compoundsof Table A1.

TABLE N31

[0986] Table N31 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N32

[0987] Table N32 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N33

[0988] Table N33 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N34

[0989] Table N34 provides 352 compounds of formula-(b) wherein R¹ ismethyl; R²is bromo; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N35

[0990] Table N35 provides 352 compounds of formula (Ib)wherein R¹ ismethyl; R² is cyano; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur, n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N36

[0991] Table N36 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur; n is0; and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N37

[0992] Table N37 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N38

[0993] Table N38 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N39

[0994] Table N39 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N40

[0995] Table N40 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH(CH₃)₂; X is oxygen; Y is sulphur; n is 0;and the values of R⁴ match those of the correspondingly numberedcompounds of Table A1.

TABLE N41

[0996] Table N41 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE N42

[0997] Table N42 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE N43

[0998] Table N43 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE N44

[0999] Table N44 provides 352 compounds of formula (ab) wherein R¹ ismethyl; R² is bromo; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R¹ ishydrogen; n is 0; and the values-of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE N45

[1000] Table N45 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R¹ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE N46

[1001] Table N46 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE N47

[1002] Table N47 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE N48

[1003] Table N49 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE N49

[1004] Table N49 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of R⁴ match those of thecorrespondingly numbered compounds of Table A1.

TABLE N50

[1005] Table N50 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is cyano; R³ is CH(CH₃); X is oxygen; Y is NR⁷; R⁷ ishydrogen; n is 0; and the values of ⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE N51

[1006] Table N51 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is hydrogen; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R¹ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE N52

[1007] Table N52 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is fluoro; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE N53

[1008] Table N53 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is chloro; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE N54

[1009] Table N54 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is bromo; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE N55

[1010] Table N55 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R¹ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE N56

[1011] Table N56 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is hydrogen; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R³ ismethyl; n is 0; and the values of ⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE N57

[1012] Table N57 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is fluoro; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R¹ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE N58

[1013] Table N58 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is chloro; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE N59

[1014] Table N59 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R² is bromo; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R⁷ is methyl;n is 0; and the values of R¹ match those of the correspondingly numberedcoinpounds of Table A1.

TABLE N60

[1015] Table N60 provides 352 compounds of formula (Ib) wherein R¹ isethyl; R¹ is cyano; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R¹ is methyl;n is 0; and the values of R¹ match those of the correspondingly numberedcompounds of Table A1.

TABLE N61

[1016] Table N61 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R¹ is hydrogen; R³is CH(CH₃)₂; X is oxygen; Y is NR⁷; R¹ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE N62

[1017] Table N62 provides 352 compounds of formula (Ia) wherein R¹ ismethyl; R² is fluoro; R³is CH(CH₃)₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE N63

[1018] Table N63 provides 3 52 compounds of formula (Ia) wherein R¹ ismethyl; R² is chloro; R³ is CH(CH₃)2; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE N64

[1019] Table N64 provides 3 52 compounds of formula (Ia) wherein R¹ ismethyl; R² is bromo; R³ is CH(CH₃)₂; X is oxygen; Y is NR⁷; R⁷ ismethyl; n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE N65

[1020] Table N65 provides 352 compounds of formula (Ib) wherein R¹ ismethyl; R² is cyano; R³ is CH(CH₃)₂; X is oxygen;, Y is NR⁷; R⁷ ismethyl;, n is 0; and the values of R⁴ match those of the correspondinglynumbered compounds of Table A1.

TABLE N66

[1021] mp = melting point ppm = parts per million s = singlet b = broadd = doublet dd = doublet of doublets t = triplet q = quartet m =multiplet J_(AB =) coupling constant between atom A and atom B

[1022] TABLE W Compound Melting NMR proton shifts (/ppm) No (Table No)point (/° C.) (CDCl₃ unless otherwise stated.) 15 (A1) 130-1312.3(s,3H); 2.8(s,2H); 3.9(s,2H); 6.5(s,1H); 7.25(dd,1H); 7.5(d,1H);7.6(d,1H); 8.9(b,1H). 1 (A3) 164-165 2.4(s,3H); 4.0(s,2H); 7.4(dd,1H);7.65(d,1H); 7.8(d,1H); 8.1(b,1H); 8.15(s,1H). 2 (A3) 161-163 2.35(s,3H);2.7(s,3H); 3.9(s,2H); 7.3(m,1H); 7.5(d,1H); 7.6(d,1H); 8.05(b,1H). 3(A3) 169-171 1.45(t,3H); 2.35(s,3H); 3.0(q,2H); 4.0(s,2H); 7.25(dd,1H);7.5(d,1H); 7.6(d,1H); 8.1(b,1H). 4 (A3) 153-155 1.05(t,3H); 1.9(m,2H);2.35(s,3H); 3.95(t,2H), 4.0(s,2H); 7.35(dd,1H). 5 (A3) 146-1470.98(t,3H); 1.5(m,2H); 1.9(m,2H); 2.4(s,3H); 2.95(t,2H); 4.0(s,2H);7.3(dd,1H); 7.5(d,1H); 7.65(d,1H); 8.05(b,1H). 8 (A3) 167-1681.45(d,6H); 2.35(s,3H); 3.25(m,1H); 3.95(s,2H); 7.25(dd,1H); 7.5(d,1H);7.6(d,1H); 8.1(b,1H). 9 (A3) 144-145 1.5(s,9H); 2.35(s,3H); 4.0(s,2H);,7.3(dd,1H); 7.55(d,1H); 7.65(d,1H); 8.1(b,1H). 10 (A3) 136-1370.95(t,3H); 1.45(d,3H); 1.9(m;2H); 2.4(s,3H); 3.1(m,1H); 4.0(s,2H);7.3(dd,1H); 7.55(d,1H): 7.65(s,1H); 8.1(b,1H). 12 (A3) 84-86 0.9(t,3H);1.4(m,2H); 1.45(d,3H); 1.7(m,1H); 1.9(m,1H); 2.4(d,2H); 3.15(m,1H);4.0(s,2H); 7.3(dd,1H); 7.5(d,1H); 7.65(d,1H); 8.2(b,1H). 13 (A3) 127-1290.9(m,6H); 1.85(m,4H); 2435(s,3H); 2.9(m,1H); 4.0(s,2H); 7.25(dd,1H);7.55(d,1H);7.65(d,H); 8.15(b,1H). 14 (A3) 118-119 1.05(d,6H); 2.3(m,1H);2.4(s,3H); 2.8(d,2H); 3.95(s,2H); 7.25(dd,1H); 7.5(d,1H); 7.6(d,1H);8.1(b,1H). 15 (A3) 144-145 1.1(s,9H);2.35(s,3H); 2.85(s,2H); 3.95(s,2H);7.25(dd,1H); 7.55(d,1H); 7.65(d,1H); 8.1(b,1H). 21 (A3) 193-1941.25(m,4H); 2.2(m,1H); 2.35(s,3H); 4.0(s,2H); 7.2(dd,1H); 7.5(d,1H);7.55(d,1H); 8.1(b,1H). 28 (A3) 158-159 1.8(m,4H); 2.1(m,4H); 2.4(s,3H);3.4(m,1H); 4.0(s,3H); 7.25(dd,1H); 7.5(d,1H); 7.6(d,1H); 8.1(b,1H). 35(A3) 144-146 1.4(m,3H); 1.7(m,3H); 1.9(m,2H); 2.2(m,2H); 2.4(s,3H);3.0(m,1H); 4.0(s,2H); 7.3(dd,1H); 7.5(d,1H); 7.6(d,1H); 8.1(b,1H). 36(A3) 140-141 1.2(s,3H); 1.3(m,2H); 1.55(m,4H); 2.15(m,2H); 2.3(m,2H);2.4(s,3H); 4.0(s,2H); 7.3(dd,1H); 7.5(d,1H); 7.65(d,1H); 8.15(b,1H). 41(A3) 165-167 0.35(m,2H); 0.65(m,2H); 1.25(m,1H); 2.4(s,3H); 2.9(d,2H);4.0(s,2H); 7.3(dd,1H); 7.55(d,1H); 7.65(d,1H); 8.1(b,1H). 42 (A3)118-119 1.3(m,2H); 1.7(m,4H); 1.9(m,2H); 2.4(s,3H); 2.5(m,1H);2.95(d,2H); 4.0(s,2H); 7.3(dd,1H); 7.5(d,1H); 7.6(d,1H); 8.1(b,1H). 45(A3) 176-178 2.05(m,3H); 2.35(s,3H); 4.0(s,2H); 6.5(dd,1H); 7.1(m,1H);7.3(dd,1H); 7.5(d,1H); 7.65(dd,1H); 8.1(b,1H). 46(A3) 145-1472.05(s,3H); 2.35(s,3H); 2.36(s,3H); 4.0(s,2H); 6.25(m,1H); 7.25(dd,1H);7.5(d,1H); 7.65(d,1H); 8.1(b,1H). 47(A3) 151-152 1.95(dd,3H); 2.2(d,3H);2.35(s,3H); 3.95(s,2H); 7.0(m,1H); 7.25(dd,1H); 7.5(d,1H); 7.65(d,1H);8.05(b,1H). 63(A3) 209-210 (CDCl₃/d₆-DMSO): 2.35(s,3H); 4.05(s,2H);7.2(d,1H); 7.4(dd,1H); 7.55(d,1H); 7.8(m,4H); 8.3(d,2H). 73(A3) 146-1472.4(s,3H); 4.0(s,2H); 5.6(d,2H,J_(Hf) = 7Hz); 7.4(dd,1H); 7.6(d,1H);7.75(d,1H); 8.1(b,1H). 75(A3) 187-188 2.4(s,3H); 4.0(s,2H); 7.5(dd,1H);7.7(d,1H); 7.85(d,1H); 8.1(b,1H). 79(A3) 128-129 2.4(s,1H); 4.0(s,2H);6.3(m,1H); 7.5(dd,1H); 7.7(d,1H); 7.85(d,1H); 8.15(b,1H). 80(A3) 141-1422.4(s,3H); 4.05(s,2H); 7.55(dd,1H); 7.7(d,1H); 7.9(d,1H); 8.15(b,1H).86(A3) 2.4(s,3H); 4.0(s,3H); 7.5(dd,1H); 7.7(d,1H); 7.9(d,1H);8.2(b,1H). 93(A3) 183-185 2.05(d,3H); 2.4(s,3H); 4.0(s,2H); 5.25(q,1H),7.4(dd,1H); 7.6(d,1H); 7.7(d,1H); 8.1(b,1H). 95(A3) 163-164 1.1(t,3H);2.4(m,2H); 2.4(s,3H); 4.0(s,2H); 5.0(t,1H); 7.4(dd,1H); 7.6(d,1H);7.7(dd,1H); 8.1(b,1H). 98(A3) 130-131 1.6(s,6H); 2.35(s,3H); 3.9(s,2H);4.0(s,2H); 7.3(dd,1H); 7.6(d,1H); 7.7(d,1H); 8.1(b,1H). 103(A3) 165-1672.4(s,3H); 4.0(s,2H); 7.5(dd,1H); 7.7(d,1H); 7.8(d,1H); 8.1(b,1H).113(A3) 192-194 2.4(s,3H); 4.0(s,2H); 4.15(s,2H); 7.4(dd,1H); 7.6(d,1H);7.7(dd,1H); 8.1(b,1H). H5(A3) 165-166 1.9(d,3H); 2.4(s,3H); 4.0(s,2H);4.3(q,1H); 7.4(dd,1H); 7.6(d,1H); 7.7(d,1H); 8.1(b,1H). 130(A3) 124-1252.35(s,3H); 3.55(s,3H); 4.0(s,2H); 4.75(s,2H); 7.35(dd,1H); 7.6(d,1H);7.7(d,1H); 8.1(b,1H). 140(A3) 126-129 2.4(s,3H); 4.0(s,2H); 5.35(s,2H);7.05(m,3H); 7.35(m,3H); 7.6(d,1H); 7.7(d,1H); 8.13(b,1H). 172(A3)123-124 2.2(s,3H); 2.4(s,3H); 3.05(m,2H); 3.3(m,2H); 4.0(s,3H);7.3(dd,1H); 7.55(d,1H); 7.65(d,1H); 8.1(b,1H). 173(A3) 163-1642.4(s,3H); 4.0(s,2H); 4.3(s,2H); 7.3(m,4H); 7.45(m,2H); 7.55(d,1H);7.6(d,1H); 8.1(b,1H). 174(A3) 147-148 2.4(s,3H); 4.0(s,2H); 7.35(dd,1H);7.55(d,1H); 7.65(d,1H); 8.1(b,1H). 180(A3) 151-153 1.3(t,3H);2.35(s,3H); 3.2(s,3H); 3.6(q,2H), 3.9(s,3H); 6.9(dd,1H); 7.25(m,2H);8.1(b,1H). 183(A3) 181-183 1.5(s,9H); 2.35(s,3H); 3.9(s,2H); 5.0(b,1H);6.95(dd,1H); 7.25(s,1H); 7.3(dd,1H); 8.1(b.1H). 191(A3) 172-1732.4(s,3H); 3.7(m,4H); 3.85(m,4H); 3.9(s,2H); 7.0(dd,1H); 7.3(m,2H);8.1(b,1H). 203(A3) 151-152 2.4(s,3H); 3.95(s,2H); 4.2(s,3H);7.15(dd,1H); 7.4(d,1H); 7.45(d,1H), 8.05(b,1H). 204(A3) 130-1311.5(t,3H); 2.4(s,3H); 3.95(s,2H); 4.6(q,2H); 7.1(dd,1H); 7.4(m,2H);8.05(b,1H). 206(A3) 158-159 1.5(d,6H); 2.4(s,3H); 3.9(s,2H); 5.3(m,1H);7.1(dd,1H); 7.38(d,1H); 7.4(d,1H); 8.1(b,1H). 220(A3) 152-154 2.4(s,3H);2.8(s,3H); 3.95(s,2H); 7.2(dd,1H); 7.5(d,1H); 7.55(d,1H); 8.05(b,1H).221(A3) 148-149 1.5(t,3H); 2.4(s,3H); 3.35(q,2H); 3.95(s,2H);7.2(dd,1H); 7.5(d,1H); 7.6(dd,1H); 8.05(b,1H). 223(A3) 113-1151.5(d,6H); 2.35(s,3H); 3.9(s,2H); 4.05(m,1H); 7.2(dd,1H); 7.45(d,1H);7.65(d,1H); 8.1(b,1H). 224(A3) 101-102 1.2(s,9H); 2.4(s,3H); 3.95(s,2H);7.25(dd,1H); 7.5(d,1H); 7.6(d,1H); 8.1(b,1H). 228(A3) 203-2052.25(s,3H); 4.0(s,2H); 4.45(s,2H); 7.3(dd,1H); 7.6(b,2H); 11.75(s,1H).229(A3) 149-150 2.4(s,3H); 3.8(s,3H); 4.0(s,2H); 4.15(s,2H); 7.2(dd,1H);7.5(d,1H); 7.55(d,1H); 8.05(b,1H). 239(A3) 201-202 2.35(s,3H);4.0(s,2H); 4.4(s,2H); 7.3(dd,1H); 7.55(d,1H); 7.6(d,1H); 8.1(b,1H).244(A3) 196-197 2.4(s,3H); 4.0(s,2H); 4.7(s,2H); 7.3(dd,1H); 7.55(d,1H);7.6(d,1H); 7.65(s,2H); 8.05(b,1H). 246(A3) 75-77 2.4(s,3H); 3.95(s,2H);5.8(s,1H); 7.3(m,11H); 7.5(d,1H); 7.7(d,1H); 8.3(b,1H). 247(A3) 114-1152.4(s,3H); 3.25(m,4H); 4.0(s,2H); 7.25(m,6H); 7.5(d,1H); 7.65(d,1H);8.1(b,1H). 248(A3) 208-209 2.4(s,3H); 4.0(s,2H); 7.3(dd,1H); 7.5(m,3H);7.6(d,1H); 7.7(d,1H); 8.15(b,1H); 8.25(m,2H). 252(A3) 152-1531.35(s,9H); 2.35(s,3H); 4.0(s,2H); 7.3(dd,1H); 7.55(d,2H); 7.6(d,1H);7.7(d,1H); 8.1(b,1H); 8.2(d,2H). 253(A3) 175-176 2.4(s,3H); 4.0(s,2H);7.45(m,3H); 7.6(dd,1H); 7.7(d,1H); 7.8(d,1H); 8.1(b,H); 8.2(m,1H).257(A3) 189-191 2.4(s,3H); 4.0(s,2H); 7.4(m,2H); 7.6(d,1H); 7.65(dd,1H);7.8(d,1H); 8.1(b,1H); 8.15(d,1H). 261(A3) 216-217 2.4(s,3H); 4.0(s,2H);7.4(dd,1H); 7.5(m,1H); 7.65(d,1H); 7.75(d,1H); 8.1(b,1H); 8.15(d,2H).267(A3) 2.4(s,3H); 4.05(s,2H); 7.45(dd,1H); 7.7(d,1H); 7.85(d,1H);8.1(b,1H); 8.8(m,1H); 8.45(m,2H). 272(A3) 212-214 (CDCl₃/d₆-DMSO):2.4(s,3H); 4.1(s,2H); 7.3(m,2H); 7.4(dd,1H); 7.55(m,1H); 7.6(d,1H);7.8(d,1H); 8. 1(m,1H); 10.4(b,1H). 278(A3) 2.4(s,3H); 4.05(s,2H);7.15(m,2H); 7.4(dd,1H); 7.5(m,1H); 7.7(d,1H); 7.85(d,1H); 8.12(b,1H).287(A3) 215-216 2.4(s,3H); 4.05(s,2H); 7.45(dd,1H); 7.7(d,1H);7.85(d,1H); 8.1(b,1H). 305(A3) 184-185 2.4(s,3H); 3.95(s,3H); 4.0(s,2H);7.1(m,1H); 7.35(m.1H); 7.45(t,1H); 7.65(d,1H); 7.75(d,1H); 7.8(m,1H);7.85(m,1H); 8.1(b,1H). 307(A3) 211-212 2.4(s,3H); 3.9(s,3H); 4.0(s,2H);7.05(m,2H); 7.3(dd,1H); 7.6(d,1H); 7.2(d,1H); 8.1(b,1H); 8.2(m,2H).329(A3) 255-256 2.4(s,3H); 3.95(s,3H); 4.0(s,2H); 7.4(dd,1H);7.65(d,1H); 7.75(d,1H); 8.1(1,1H); 8.2(d,2H); 8.3(d,2H). 330(A3) 181-1832.4(s,3H); 4.0(s,2H); 7.2(m,1H); 7.3(dd,1H); 7.6(m,2H); 7.7(d,1H);7.9(m,1H); 8.1(b,1H). 331(A3) 193-194 2.4(s,3H); 4.0(s,2H); 7.1(d,1H);7.35(dd,1H); 7.53(d,1H); 7.65(d,1H); 7.75(d,1H); 8.1(b,1H). 334(A3)143-144 2.4(s,3H); 4.0(s,2H); 4.5(s,2H); 7/0(m,1H); 7.05(m,1H);7.25(m,1H); 7.3(dd,1H); 7.55(d,1H); 7.65(d,1H); 8.1(b,1H). 339(A3) 245(CDCl₃/d₆-DMSO): 2.4(s,3H); 4.1(s,2H); 7.45(dd,1H); 7.6(d,1H);7.8(d,1H); 8.1(m,2H); 8.8(m,2H); 10.6(b,1H). 343(A3) 183-184 2.4(s,3H);4.0(s,2H); 7.4(dd,1H); 7.45(m,1H); 7.7(d,1H); 7.8(d,1H); 8.1(b,1H);8.5(m,1H); 8.6(m,1H). 349(A3) 171-173 2.4(s,3H); 4.05(s,2H); 7.15(d,1H);7.5(dd,1H); 7.7(d,1H); 7.8(d,1H); 8.2(b,1H); 8.5(d,1H). 351(A3)(CDCl₃/d₆DMSO): 2.25(s,3H); 3.9(s,2H); 6.95(m,2H); 7.15(d,1H);11.55(s,1H). 352(A3) (CDCl₃/d₆-DMSO); 2.4(s,3H); 3.95(s,2H); 7.2(m,3H);10.9(s,1H); 13.4(s,1H). 2(A4) 156-157 2.4(s,3H); 2.7(s,3H); 4.0(s,2H);7.25(dd,1H); 7.5(d,1H); 7.6(d,1H); 8.1(b,1H). 15(A4) 115-117 1.1(s,9H);2.45(s,3H); 2.9(s,2H); 4.1(s,2H), 7.35(dd,1H); 7.55(d,1H); 7.7(d,1H);8.75(b,1H). 2(A5) 213-214 2.5(s,3H); 2.65(s,3H); 4.0(s,2H); 7.3(dd,1H);7.5(d,1H); 7.6(d,1H); 9.7(b,1H); 15(A5) 134-135 1.1(s,9H); 2.5(s,3H);2.8(s,2H); 4.0(s,2H); 7.3(dd,1H); 7.5(d,1H); 7.65(d,1H); 9.8(b,1H).2(A8) 165-167 1.25(t,3H); 2.7(s,3H); 2.7(q,2H); 4.0(s,2H); 7.25(dd,1H);7.5(d,1H); 7.6(d,1H); 8.1(b,81H). 15(A8) 126-127 1.1(s,9H); 1.3(t,3H);2.7(q,2H); 2.8(s,2H); 4.0(s,2H); 7.3(dd,1H); 7.5(d,1H); 7.65(d,1H);8.1(b,1H). 2(A13) 160-164 2.35(s,3H); 2.85(s,3H); 4.0(s,2H);7.35(dd,1H); 7.9(m,2H); 8.15(bs,1H). 4(A13) gum 1.1(t,3H); 1.95(m,2H);2.4(s,3H); 3.1(t,2H); 4.0(s,2H); 7.35(dd,1H); 7.85(d,1H); 7.9(d,1H);8.3(b,1H). 8(A13) 134-136 1.5(d,6H); 2.35(s,3H); 3.5(m,1H); 4.0(s,2H);7.35(dd,1H); 7.85(m,4H); 8.25(b,1H). 9(A13) gum 1.5(s,9H); 2.35(s,3H);4.0(s,2H); 7.35(dd,1H); 7.9(d,1H); 7.95(s,1H); 8.15(b,1H). 15(A13) gum1.1(s,9H); 2.35(s,3H); 2.95(t,2H); 4.0(s,2H); 7.35(dd,1H); 7.85(d,1H);7.95(d,1H), 8.25(b,1H). 2(A23) 170-172 2.4(s,3H); 2.65(s,3H); 4.0(s,2H);7.25(dd,1H); 7.5(d,1H); 7.7(b,1H) 8.1(b,1H). 4(A23) 95-97 1.05(t,3H);1.95(m,2H); 2.4(s,3H); 2.95(t,2H); 4.0(s,2H); 7.35(m,1H); 7.5(s,1H);7.7(d,1H); 8.2(b,1H). 15(A23) gum 1.05(s,9H); 2.4(s,3H); 2.8(s,2H);4.0(s,2H); 7.25(d,1H); 7.5(b,1H); 7.7(d,1H); 8.45(b,1H). 2(A43)(CDCl₃/d₆-DMSO): 2.3(s,3H); 2.6(s,3H); 4.0(s,2H); 7.15(d,1H); 7.5(m,2H);9.3(b,1H). 4(A43) (CDCl₃/d₆-DMSO): 1.0(t,3H); 1.8(m,2H); 2.4(s,2H);2.9(t,2H); 4.0(s,2H); 7.2(dd,1H); 7.5(d,1H); 7.6(d,1H). 9(A43)(CDCl₃/d₆-DMSO): 1.6(s,9H); 2.4(s,2H); 4.0(s,2H); 7.2(dd,1H);7.55(b,2H). 15(A43) (CDCl₃/d₆-DMSO): 1.1(s,9H); 2.4(s,3H); 2.8(s,2H);3.8(s,2H); 7.2(dd,1H); 7.5(b,1H); 7.6(b,1H). 248(A43) (CDCl₃/d₆-DMSO):2.3(s,3H); 3.9(s,2H); 7.1(dd,1H); 7.45(m,4H); 7.55(m,1H); 8.1(m,2H);8.75(b,1H). 2(B3) 97-98 2.5(s,3H); 2.6(s,3H); 3.3(b,3H); 3.7(b,2H);7.05(b,1H); 7.35(b,2H). 4(B3) 75-76 1.05(t,3H); 1.9(m,2H); 2.5(s,3H);2.9(t,2H); 3.25(b,3H); 3.65(b,2H); 7.05(b,1H); 7.4(b,2H). 15(B3) 80-90(d₆-DMSO): 1.0(s,9H); 2.3(s,3H); 2.75(s,2H); 3.4(s,3H); 3.85(s,2H);7.1(dd,1H); 7.4(b,1H); 7.5(d,1H). 2(C3) gum 1.15(t,3H); 2.5(s,3H);2.6(s,3H); 3.6(b,2H); 3.8(b,2H); 7.05(b,1H); 7.35(b,2H). 4(C3) gum1.0(t,3H); 1.2(t,3H); 1.9(m,2H); 2.5(s,3H); 2.9(t,2H); 3.6(b,2H);3.8(b,2H); 7.05(b,1H); 7.4(b,2H). 15(C3) 53-54 1.05(s,9H); 1.2(t,3H);2.5(s,3H); 2.8(s,2H); 3.6(b,2H); 3.75(b,2H); 7.05(b,1H); 7.4(b,2H).2(D3) gum 0.9(s,3H); 1.6(m,2H); 2.5(s,3H); 2.6(s,3H); 3.6(b,2H);3.7(b,2H); 7.05(b,1H); 7.35(b,2H). 4(D3) gum 0.9(t,3H); 1.05(t,3H);1.55(m,2H); 1.9(m,2H); 2.5(s,3H); 2.9(t,2H); 3.6(b,2H); 3.7(b,2H),7.05(b,1H); 7.35(b,2H). 15(D3) gum 0.9(t,3H); 1.05(s,9H); 1.55(m,2H);2.5(s,3H); 2.8(s,3H); 3.65(m,4H); 7.05(b,1H); 7.35(b,2H). 2(E3) gum2.5(s,3H); 2.6(s,3H); 3.65(b,2H); 4.3(b,2H); 5.2(b,2H); 5.8(b,1H);7.05(b,1H); 7.35(b,2H). 4(E3) gum 1.05(t,3H); 1.9(m,2H); 2.5(s,3H);2.9(t,2H); 3.65(b,2H); 4.3(b,2H); 5.2(b,2H); 5.8(b,1H); 7.05(b,1H);7.4(b,2H). 15(E3) gum 1.1(s,9H); 2.5(s,3H); 2.8(s,2H); 3.7(b,2H);4.3(b,2H); 5.2(b,2H); 5.8(b,1H); 7.05(b,1H); 7.4(b,2H). 2(F3) gum2.3(b,1H); 2.5(s,3H); 2.6(s,3H); 3.65(b,2H); 4.5(b,2H); 7.05(b,1H);7.35(b,2H). 4(F3) gum 1.05(t,3H); 1.9(m,2H); 2.3(b,1H); 2.5(s,3H);2.9(t,2H); 3.65(b,2H); 4.5(b,2H); 7.05(b,1H); 7.4(b,2H). 15(F3) gum1.05(s,9H); 2.3(b,1H); 2.5(s,3H); 2.8(s,2H); 3.65(b,2H); 4.5(b,2H);7.05(b,1H); 7.4(b,2H). 15(H3) 93-95 1.05(s,9H); 2.5(s,3H); 2.8(s,2H);3.7(s,2H); 4.3(b,2H); 7.0(dd,1H); 7.3(b,1H); 7.4(b,1H). 2(K3) gum2.5(s,3H); 2.6(s,3H); 3.4(s,3H); 3.5(m,2H); 3.7(b,2H); 3.75(m,2H);5.15(b,2H); 7.05(b,1H); 7.4(b,2H). 4(K3) gum 1.05(t,3H); 1.9(m,2H);2.5(s,3H); 2.9(t,2H); 3.35(s,3H); 3.5(m,2H); 3.7(b,2H); 3.75(m,2H); 5.15(b,2H); 7.05(b,1H); 7.4(b,2H). 15(K3) gum 1.05(s,9H); 2.5(s,3H);2.8(s,2H); 3.35(s,3H); 3.5(m,2H); 3.7(b,2H); 3.75(m,2H); 5.15(b,2H);7.05(b,1H); 7.4(b,2H). 2(L3) gum 1.2(t,3H); 2.5(s,3H); 2.6(s,3H);3.6(q,2H); 3.7(b,2H); 5.1(b,2H); 7.05(b,1H); 7.4(b,2H). 4(L3) gum1.05(t,3H); 1.2(t,3H); 1.9(m,2H); 2.5(s,3H); 2.9(t,2H); 3.6(q,2H);3.7(b,2H); 5.1(b,2H); 7.05(b,1H); 7.4(b,2H). 15(L3) gum 1.05(s,9H);1.2(t,3H); 2.5(s,3H); 2.8(s,2H); 3.6(q,2H); 3.7(b,2H); 5.1(b,2H);7.05(b,1H); 7.4(b,2H). 2(M3) gum 2.5(s,3H); 2.6(s,3H); 3.4(s,3H);3.5(m,2H); 3.7(b,2H); 3.75(m,2H); 5.15(b,2H); 7.05(b,1H); 7.4(b,2H).4(M3) gum 1.05(t,3H); 1.9(m,2H); 2.5(s,3H); 2.9(t,2H); 3.35(s,3H);7.4(b,2H). 15(M3) gum 1.05(s,9H); 2.5(s,3H); 2.8(s,2H); 3.35(s,3H);3.5(m,2H); 3.7(b,2H); 3.75(m,2H); 5.15(b,2H); 7.05(b,1H); 7.4(b,2H).15(N3) 80-81 1.0(b,3H); 1.05(s,9H); 1.2(b,3H); 2.5(s,3H); 2.8(s,2H);3.55(b,2H); 5.0(m,1H); 7.05(b,1H); 7.4(m,2H). 15(V3) 160-161 1.1(s,9H);2.4(s,3H); 2.85(s,2H); 4.4(s,2H); 7.3(dd,1H); 7.6(d,1H); 7.7(d,1H);9.3(b,1H)

[1023] Registered Trade Mark Composition SYNPERONIC NP8 }Nonylphenol-ethylene oxide condensate SYNPERONIC NP13 } SYNPERONIC A7Synthetic primary alcohol-ethylene oxide condensate AROMASOL HAlkylbenzene solvent SOLVESSO 200 Inert organic diluent KELTROLPolysaceharide PROXEL Bactericide

[1024]

% by weight Compound No. 4 (Table A23) 25.0 SYNPERONIC NP13 2.5 Calciumdodecylbenzenesulphonate 2.5 AROMASOL H 70.0

[1025] % by weight Compound No. 272 (Table A3) 25.0 Silica 25.0 Sodiumlignosulphonate 5.0 Sodium lauryl sulphate 2.0 Kaolin 43.0

[1026] % by weight Compound No. 4 (Table K3) 1.0 Talc 99.0

[1027] % by weight Compound No. 2 (Table D3) 10.0 SOLVESSO 200 90.0

[1028] % by weight Compound No. 15 (Table H3) 10.0 AROMASOL H 10.0Toluene di-isocyanate 3.0 SYNPERONIC A7 1.0 Polyvinyl alcohol 2.0Bentonite 1.5 KELTROL 0.1 Water 72.4

[1029] % by weight Compound No. 251 (Table A43) 0.5 SOLVESSO 200 0.2SYNPERONIC A7 0.1 Calcium carbonate granules (diameter 0.3-0.7 mm) 99.2

[1030] % by weight Compound No. 4 (Table E3) 0.5 Sodium lignosulphonate5.0 Kaolin 94.5

[1031] % by weight Compound No. 331 (Table A3) 25.0 Sodiumlignosulphonate 3.0 Propylene glycol 10.0 Bentonite 2.0 KELTROL 0.1PROXEL 0.1 Water 59.8

[1032] % by weight Compound No. 343 (Table A3) 25.0 Silica 5.0 Sodiumlignosulphonate 10.0 Sodium lauryl sulphate 5.0 Sodium acetate 10.0Montmorillonite powder 45.0

[1033] TABLE X1 Compound No. MUSCDO MUSCDO (Table No.) TETRUR MYZUPE ACAK HELIVI LAPHEG MELGIN  4 (A3) 5 9 9 9 9 5 9  15 (A3) 9 9 9 0 9 9 0  2(A3) 0 9 0 0 5 0 5  9 (A3) 9 5 9 0 9 5 0 248 (A3) 0 0 0 0 5 0 0 257 (A3)9 0 0 5 5 0 5  1 (A3) 0 5 0 0 0 0 5  8 (A3) 0 5 9 9 5 5 0  3 (A3) 5 9 99 9 5 0 140 (A3) 0 0 0 0 0 0 0 220 (A3) 0 5 5 0 0 0 0  14 (A3) 9 9 9 5 99 0 221 (A3) 0 9 9 5 0 0 0 223 (A3) 0 9 0 0 5 0 0  10 (A3) 0 9 5 0 5 5 0252 (A3) 0 0 0 0 0 0 0  46 (A3) 5 9 5 5 0 5 0  13 (A3) 9 9 9 5 0 0 0 329(A3) 0 0 0 0 0 0 N/T  47 (A3) 0 9 0 0 0 0 0 247 (A3) 0 9 0 0 0 0 0 331(A3) 0 0 0 0 0 0 N/T  98 (A3) 9 9 5 0 5 5 0  45 (A3) 5 9 9 9 5 9 0  5(A3) 0 9 0 0 5 5 0  28 (A3) 9 9 5 9 9 5 0 172 (A3) 9 9 5 9 5 5 5 261(A3) 0 0 0 0 0 0 0 224 (A3) 9 9 0 0 5 0 0 351 (A3) 0 0 0 0 0 0 0  15(B3) 9 5 0 0 0 0 0  15 (D3) 9 9 0 0 5 5 0  15 (K3) 9 9 0 0 5 5 0  15(L3) 9 9 9 9 9 5 0  15 (M3) 9 9 0 0 0 5 0  15 (C3) 9 9 9 0 0 9 0  73(A3) 0 9 0 0 5 0 0  41 (A3) 5 9 0 9 5 5 0  2 (A23) 0 0 0 0 0 0 0  4(A23) 0 9 0 0 0 0 0  15 (A23) 9 5 0 0 0 5 0  2 (K3) 9 9 9 0 0 0 0  2(B3) 0 0 9 0 0 0 0  4 (B3) 0 5 0 0 0 5 0  15 (F3) 9 9 0 0 9 9 0  2 (L3)9 9 9 0 9 5 0  2 (M3) 0 5 0 0 0 0 0  4 (L3) 9 9 9 5 9 9 0  4 (K3) 0 5 00 0 5 0  15 (E3) 9 9 0 0 9 5 0  2 (C3) 9 5 9 0 0 5 0  4 (M3) 0 9 0 0 0 00  4 (C3) 9 9 0 5 0 9 0 352 (A3) 0 5 0 0 0 0 0  2 (E3) 0 0 0 0 0 0 0  2(F3) 0 9 0 0 0 0 0  4 (F3) 5 9 0 5 0 9 0  4 (E3) 5 9 0 0 0 0 0  2 (D3) 00 0 0 0 0 0  4 (D3) 9 5 0 0 0 5 0 228 (A3) 0 0 0 0 0 0 0  2 (A13) 0 0 00 0 0 5  15 (V3) 9 5 0 0 0 0 0 180 (A3) 0 0 0 0 0 5 0  4 (A13) 9 9 9 9 0N/T 0 183 (A3) 9 0 0 5 5 5 0 203 (A3) 0 9 9 9 0 0 0 174 (A3) 0 5 0 0 0 00  2 (A43) 0 0 0 0 0 0 5 229 (A3) 0 0 0 0 0 0 0 191 (A3) 9 0 5 5 5 0 9 15 (A1) 9 0 5 0 0 0 0  15 (A4) 9 9 9 9 0 9 0 204 (A3) 0 9 9 9 5 9 0  2(A4) 0 5 5 5 0 N/T 0  9 (A43) 5 9 0 0 0 N/T 0 339 (A3) 9 0 0 0 0 N/T 0 35 (A3) 9 9 0 0 0 N/T 0  15 (N3) 0 0 0 0 0 N/T 0 113 (A3) 9 0 0 0 0 N/T0  80 (A3) 0 0 0 0 0 N/T 0

[1034] TABLE X2 Compound No. (Table No.) TETRUR MYZUPE HELIVI MELGIN 287(A3) 0 0 0 0  15 (A5) 5 0 0 0  2 (A5) 0 5 0 5  2 (A8) 0 5 0 0  15 (A8) 99 5 0 330 (A3) 0 0 0 0 349 (A3) 0 0 0 0 173 (A3) 0 0 0 0 334 (A3) 0 0 00 272 (A3) 0 0 0 0 253 (A3) 0 5 0 0  42 (A3) 9 5 0 0 305 (A3) 0 0 0 0 86 (A3) 5 5 0 0  12 (A3) 5 5 0 9  93 (A3) 0 0 0 0 246 (A3) 0 0 0 0  36(A3) 9 5 0 0 267 (A3) 0 5 0 0  79 (A3) 0 0 5 0 130 (A3) 5 9 0 0  95 (A3)0 9 0 0  21 (A3) 0 5 0 0 343 (A3) 0 5 0 0  75 (A3) 0 9 0 0  15 (H3) 0 90 0 239 (A3) 0 9 0 0 244 (A3) 0 0 0 0 115 (A3) 0 5 0 0

[1035] 0 = 0% disease present 1 = 0.1-1% disease present 3 = 1.1-3%disease present 5 = 3.1-5% disease present 10 = 5.1-10% disease present20 = 10.1-20% disease present 30 = 20.1-30% disease present 60 =30.1-60% disease present 90 = 60.1-100% disease present

[1036] $\begin{matrix}{{PRCO} = {100 - {\left\{ \frac{{Banded}\quad {mean}\quad {disease}\quad {level}\quad {for}\quad {treatment}\quad A}{{Banded}\quad {mean}\quad {disease}\quad {level}\quad {on}\quad {untreated}\quad {controls}} \right\} \times 100}}} \\{= {{100 - \left( {\frac{30}{90} \times 100} \right)} = 66.7}}\end{matrix}$

$\begin{matrix}{{PRCO} = {100 - {\left\{ \frac{\quad {{Mean}\quad {disease}\quad {level}\quad {for}\quad {treatment}\quad A}}{\quad {{Mean}\quad {disease}\quad {level}\quad {on}\quad {untreated}\quad {controls}}} \right\} \times 100}}} \\{= {{100 - \left( {\frac{25}{85} \times 100} \right)} = 70.6}}\end{matrix}$

TABLE Y1 COMPOUND NO. ERYSGT ERYSGT PLASVI LEPTNO PUCCRT PHYTIN (TABLENO.) 6 hr Prot/Folr 1 d Prot/Folr 1 d Prot/Folr 1 d Prot/Folr 1 dProt/Folr 1 d Prot/Folr  4 (A3) 100* 34 50 100*  100*  15 (A3) 100* 100 71 100   100*  2 (A3) 100*  0* 21 100*  100*  9 (A3) 100* 100* 55 100 100 248 (A3)  0*  97*  0* 100*  17* 257 (A3)  0*  79*  0* 100*   0*  1(A3) 88  6 59 100  8 (A3) 20  6  0 90  3 (A3)  4 14 33 98 140 (A3) 44 6313 96 220 (A3) 12  6 17 100*  100*  14 (A3) 90 89 28 97 100 221 (A3) 5084 20 99  99 223 (A3) 73 55 12 99  93  10 (A3) 98 87 28 100  100 252(A3) 30 38 −13  97  46 (A3) 97 99 88 100   13 (A3) 100  100  58 100   93329 (A3) 30  8  0 46  47 (A3) 86 92 63 99 247 (A3) 61 62 13 95  97 331(A3) 33 49 17 95  98 (A3) 98 99 30 98 100  5 (A3) 40 39 30 88 100  28(A3) 46  0 20 86 100 172 (A3) 40 44 10 96 100 261 (A3) 19 25 −7  3  0224 (A3) 88 99 16 98 100  15 (B3) 75 79 −2 15  99  15 (D3) 55 70 25  99 15 (L3) 100  40 17  97  15 (M3)  6  98  15 (C3) 38 93 13  97  73 (A3)93 57 100  100  41 (A3) 59 77 98 100  2 (A23) −3 53 77 100  4 (A23) 5963 100  100  15 (A23) 62 83 98 100  2 (M3) 97  98  2 (B3) 96 100  4 (B3)48 100  15 (F3) 95 100  2 (L3) 93  82  2 (M3) 68  83  4 (L3) 100  100  4(K3) 100   98  15 (E3) 74  83  2 (C3) 74  50  4 (M3) 85  81  4 (C3) 96 79 352 (A3) 100  100  2 (E3) 99  98  2 (F3) 90 100  4 (F3) 100   99  4(E3) 97  95  2 (D3) 96  59  4 (D3) 90  96 228 (A3)  6  66  2 (A13) 31 6299 100  15 (V3) 87 −2 100  100 180 (A3) 29 14 69  4 (A13) 100  20 100 183 (A3) 99 19 99 100 203 (A3) 98 −3 100   85  2 (A43) 20 −3  7  18 229(A3) 21  2  6  92 191 (A3) 94 36 99  92  15 (A1) 43  4 96 100  15 (A4)91 19 99 100 204 (A3) 87 67 99 100  4 (A43)  0 31  0  15 (A43)  0  80  2(A4) 97 −12  100  100  9 (A43)  7 −4 25  0 339 (A3) −7  0 31  0  35 (A3)93 −15  100   84  15 (N3)  8 −2  3  3 113 (A3)  5 20 41  38 287 (A3) 34−2 94  3  80 (A3) 99 −2 100   45  15 (A5) 15 −2 84  45  2 (A5) 18 −2 28 19  2 (A8) 54  9 100   74  15 (A8) 80 −2  99  63 (A3) 40  2 69  66 330(A3) 87 37 99  99 173 (A3) 16  2 63  77 253 (A3) 94 94  8 99  98  42(A3) 92 92 11 99 100 305 (A3) 16 16 −2 81 74  12 (A3) 95 17 100  100  93(A3) 32 24 38  49 246 (A3) 16 27 13  79  36 (A3) 72  2 91 100  79 (A3)100  14 100  130 (A3) 87 21 100   95 (A3) 68  8 100   21 (A3) 35 14 100  75 (A3) 90 27 94  15 (H3) 16  2 29 239 (A3) 23  3 244 (A3)  3 −2 84 115(A3) −3  8 45

[1037] TABLE Y2 COMPOUND NO. UNCINE PYRIOR RHIZSO VENTIN BOTRCI (TABLENO.) 1 d Prot/Folr 1 d Prot/Folr 1 d Prot/Stem 1 d Prot/Folr 1 dProt/Folr  4 (A3) 62 81 49 49  15 (A3) 100 100 5 100 73  2 (A3) 93 92 2497 0  9 (A3) 100 100 29 83 3 248 (A3) 7 7 100 257 (A3) 61 11 0  1 (A3)43 91 25  8 (A3) 40 0 26  3 (A3) 27 0 67 140 (A3) 99 0 70 220 (A3) −5 011  14 (A3) 98 90 12 10 221 (A3) 23 93 0 25 223 (A3) 30 63 0 60  10 (A3)96 77 0 40 252 (A3) 79 46 0 −47  46 (A3) 100 92 0 84  13 (A3) 100 96 1953 329 (A3) 6 38 0 −16  47 (A3) 98 88 0 37 247 (A3) 95 85 0 −11 331 (A3)76 81 0 5  98 (A3) 100 81 96  5 (A3) 72 31 −10  28 (A3) 9 81 53 172 (A3)36 19 69 261 (A3) 17 31 0 0 224 (A3) 91 91 0 60 351 (A3) 11  15 (B3) 10069 29 5  15 (D3) 100 27 −14  15 (L3) 99 20 −21  15 (C3) 100 7 64  73(A3) 93 100 0  41 (A3) 91 33 50  2 (A23) −17 47 89  4 (A23) 99 90 95  15(A23) 100 80 0 100  2 (A13) 72 47 43  15 (V3) 100 100 0 10 180 (A3) 4242 0  4 (A13) 100 100 55 183 (A3) 98 99 98 203 (A3) 69 96 65  2 (A43) 1148 14 229 (A3) −9 55 10 191 (A3) 100 92 10  15 (A1) 100 87 54  15 (A4)100 98 54 204 (A3) 81 96 22  4 (A43) 35 38  15 (A43) 63 63  2 (A4) 90 9992  9 (A43) 7 26 38 339 (A3) 26 33 8  35 (A3) 100 98 70  15 (N3) 87 13 3113 (A3) 21 28 8 287 (A3) 20 19 8  80 (A3) 100 91 −8  15 (A5) 83 81 3  2(A5) 3 31 19  2 (A8) 74 75 8  15 (A8) 100 81 24  63 (A3) 14 13 330 (A3)14 6 173 (A3) −12 50 253 (A3) 100 34  42 (A3) 100 74 305 (A3) 19 −6  12(A3) 100 63  93 (A3) 10 6 246 (A3) −7 13  36 (A3) 99 44  79 (A3) 90 9888 130 (A3) 86 93 60  95 (A3) 100 96 98  21 (A3) 44 92 50  75 (A3) 53 7815  15 (H3) 63 46 0 239 (A3) 51 11 5 244 (A3) −2 45 115 (A3) 2 5 15

[1038] $E = {X + Y - \frac{XY}{100}}$

Application rate/(mg of compound/litre) Observed Expected Compound ACompound B PRCO (/%) PRCO (/%) 100 0   21 —  0 0.1 48 — 100 0.1 81 59.2

[1039] TABLE ZI SEPTORIA NODORUM - Compound 15 (A3) and azoxystrobin.Test 1 Test 2 (Disease on (Disease on COMPOUND APPLICATION untreated:52%) untreated: 64%) RATE/(mg/l) % disease control % disease controlCompound 15 (A3) azoxystrobin Observed Expected Observed Expected 100 027 / 21 / 50 0 16 / 21 / 0 0.25 37 / 71 / 0 0.1 41 / 48 / 100 0.25 8954.01 92 77.09 100 0.1 84 56.93 81 58.92 50 0.25 82 47.08 80 77.09 500.1 73 50.44 75 58.92

[1040] TABLE Z2 PLASMOPARA VITICOLA - Compound 15 (A3) and azoxystrobin.(Disease COMPOUND on untreated: 95%) APPLICATION RATE/(mg/l) % diseasecontrol Compound 15 (A3) azoxystrobin Observed Expected 0.2 0   45 / 0  0.2 61 / 0.2 0.2 100  79

[1041] TABLE Z3 PLASMOPARA VITICOLA - Compound 15 (A3) and fluazinam.(Disease COMPOUND on untreated: 95%) APPLICATION RATE/(mg/l) % diseasecontrol Compound 15 (A3) fluazinam Observed Expected 0.2 0 45 / 0   1  4/ 0.2 1 96 47

[1042] TABLE Z4 PLASMOPARA VITICOLA - Compound 15 (A3) and fenamidone.(Disease COMPOUND on untreated: 95%) APPLICATION RATE/(mg/l) % diseasecontrol Compound 15 (A3) fenamidone Observed Expected 0.2 0   45 / 0  0.2 65 / 0.2 0.2 100  83

[1043] TABLE Z5 RHIZOCTONIA SOLANI - Compound 15 (A3) and azoxystrobin.Test 1 Test 1 (Disease on untreated (Disease on untreated 100%; assessed100%; assessed COMPOUND APPLICATION 5 days after treatment 5 days aftertreatment RATE/(mg/l) % disease control % disease control Compound 15(A3) azoxystrobin Observed Expected Observed Expected 300 0 2.5 / 6.1 /0 0.1 38.25 / 19.7 / 0 0.3 71.25 / / / 300 0.1 66.25 40.3 51 26.4 3000.3 87.5 71.97 / /

[1044] TABLE Z6 RHIZOCTONIA SOLANI - Compound 15 (A3) and fluazinam.Test 1 Test 1 (Disease on untreated (Disease on untreated 100%; assessed100%; assessed COMPOUND APPLICATION 5 days after treatment 5 days aftertreatment RATE/(mg/l) % disease control % disease control Compound 15(A3) fluazinam Observed Expected Observed Expected 300 0 2.5 / 6.1 / 010 48.75 / 18.4 / 0 3 15 / / / 300 10 86 50.0 79.6 23.37 300 3 40 17.125/ /

[1045]

1. A compound of formula (I):

wherein X is O or S; n is 0 or 1; Y is O, S or NR⁷; R¹ is hydrogen,halogen, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆alkylthio, C₁₋₆ haloalkylthio, C₃₋₆ cycloalkyl, C₁₋₆ alkoxy(C₁₋₆)alkylor SF₅; R² is hydrogen, halogen, C₁₋₆ alkyl, C₁₋₆ alkoxy, C₁₋₆haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, C₁₋₆haloalkyl, cyano, nitro, CHO, CH═NOR⁵, C₁₋₆ alkylcarbonyl, C₁₋₆alkoxycarbonyl or SF₅; or together R¹ and R² form a five or six memberedsaturated or-unsaturated carbocyclic ring, optionally substituted by oneor two C₁₋₆ alkyl groups; R³ is hydrogen, C₁₋₆ alkyl, CH₂(C₁₋₄haloalkyl), C₁₋₆ cyanoalkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl,C₁₋₆-alkoxy(C₁₋₆)alkyl, C₁₋₆ alkylthio(C₁₋₆)alkyl, C₁₋₆alkoxy(C₁₋₆)alkoxy(C₁₋₆)alkyl, C₁₋₆ alkylcarbonyl, C₁₋₆ alkoxycarbonyl,formyl, C₁₋₆ alkylcarbonyl(C₁₋₆)alkyl, C₁₋₆ alkoxycarbonyl(C₁₋₆)alkyl,C₁₋₆ alkylaninQcarbonyl, di(C₁₋₆)alkylaminocarbonyl, optionallysubstituted phenoxycarbonyl, optionally substituted phenyl(C₁₋₆)alkyl orS(O)_(q)R⁶; R⁴ is hydrogen, halogen, cyano, C₁₋₈ alkyl, C₁₋₆ haloalkyl,C₁₋₆ cyanoalkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₇ cycloalkyl, C₃₋₇halocycloalkyl, C₃₋₇ cyanocycloalkyl, C₁₋₃ alkyl(C₃₋₇)cycloalkyl, C₁₋₃alkyl(C₃₋₇)halocycloalkyl, C₃₋₆ cycloalkyl(C₁₋₆)alkyl, C₁₋₆cycloalkenyl, C₅₋₆ cycloalkenyl(C₁₋₆)alkyl, C₂₋₆ haloalkenyl, C₁₋₆cyanoalkenyl, C₁₋₆ alkoxy(C₁₋₆)alkyl, formyl, C₁₋₆ carboxyalkyl, C₁₋₆alkylcarbonyl(C₁₋₆)alkyl, C₁₋₆ alkoxycarbonyl(C₁₋₆)alkyl, C₁₋₆alkylthio(C₁₋₆)alkyl, C₁₋₆ alkylsulfinyl(C₁₋₆)alkyl, C₁₋₆alkylsulfonyl(C₁₋₆)alkyl, aminocarbonyl(C₁₋₆)alkyl, C₁₋₆alkylaminocarbonyl(C₁₋₆)alkyl, di(C₁₋₆)alkylaminocarbonyl(C₁₋₆)alkyl,C₁₋₆ alkoxycarbonyl, C₁₋₆ alkylcarbonyl, aminocarbonyl, C₁₋₆alkylaminocarbonyl, di(C₁₋₆)alkylaminocarbonyl, optionally substitutedphenyl, optionally substituted phenyl(C₁₋₄)alkyl, optionally substitutedphenyl(C₂₋₄)alkenyl, optionally substituted heteroaryl, optionallysubstituted heteroaryl(C₁₋₄)alkyl, optionally substituted heterocyclyl,optionally substituted heterocyclyl(C₁₋₄)alkyl, a group OR⁸, a group SH,a group S(O)_(p)R⁹, a group NR¹⁰R¹¹ or a group C(R¹²)═NOR¹³; R⁵ ishydrogen, C₁₋₆ alkyl, optionally substituted phenyl or optionallysubstituted phenyl(C₁₋₄)alkyl; R⁶ is C₁₋₆ alkyl, C₁₋₆ haloalkyl oroptionally substituted phenyl; R⁷ is hydrogen, cyano, C₁₋₈ alkyl, C₁₋₆haloalkyl, C₁₋₆ cyanoalkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₇ cycloalkyl,C₂₋₆ haloalkenyl, C₃₋₆ cycloalkyl(C₁₋₆)alkyl, C₁₋₆ alkoxy(C₁)alkyl, C₁₋₆alkoxycarbonyl, C₁₋₆ alkylcarbonyl, C₁₋₆ -alkylaminocarbonyl,di(C₁₋₆)alkylaminocarbonyl, optionally substituted phenyl or optionallysubstituted heteroaryl; R⁸ is hydrogen, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆alkenyl, C₁₋₄ cyanoalkyl, C₁₋₆ alkoxycarbonyl(C₁₋₆)alkyl, optionallysubstituted phenyl, optionally substituted phenyl(C₁₋₄)alkyl, optionallysubstituted heteroaryl, N═C(CH₃)₂; R⁹ is C₁₋₆ alkyl, C₁₋₆ haloalkyl,C₃₋₆ alkenyl, cyano, C₁₋₄cyanoalkyl, C₁₋₆ alkoxycarbonyl(C₁₋₆)alkyl,optionally substituted phenyl, optionally substituted phenyl(C₁₋₄)alkylor optionally substituted heteroaryl; R¹⁰ and R¹¹ are, independently,hydrogen, C₁₋₈ alkyl, C₃₋₇ cycloalkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₂₋₆haloalkyl, C₁₋₆ alkoxy(C₁₋₆)alkyl, C₁₋₆ alkoxycarbonyl, optionallysubstituted phenoxycarbonyl, formyl, C₁₋₆ alkylcarbonyl, C₁₋₆ alkylSO₂,optionally substituted phenylSO₂ or optionally substitutedphenyl(C₁₋₄)alkyl; R¹² C¹⁻³ alkyl; R¹³ is C₁₋₆ alkyl; R¹³ is C₁₋₆ alkyl,optionally substituted phenyl(C₁₋₂)alkyl; and p and q are,independently, 0, 1 or
 2. 2. A compound of formula (Ia) or a compound offormula (Ib):

wherein R¹, R², R³, R⁴, X, Y and n are as claimed in claim
 1. 3. Acompound of formula (1) as claimed in claim 1 or 2 wherein n is zero. 4.A compound of formula (Ia) or a compound of formula (Ib) as claimed inclaim 3 wherein R¹ is C₁₋₂ allyl.
 5. A compound of formula (Ia) or acompound of formula (Ib) as claimed in claim 3 or 4 wherein R² ishydrogen, cyano or halogen.
 6. A compound of formula (Ia) or a compoundof formula (Ib) as claimed in claim 3, 4 or 5 wherein R³ is hydrogen,C₁₋₆ alkyl or C₁₋₆ alkoxy(C₁₋₆)alkyl.
 7. A compound of formula (Ia) or acompound of formula (Ib) as claimed in claim 3, 4, 5 or 6 wherein R⁴ ishydrogen, SH, C₁₋₆ alkyl, C₃₋₆ cycloalkyl, C₂₋₆ alkenyl, C₂₋₅ alkynyl,C₁₋₄ haloalkyl, C₁₋₄ cyanoalkyl, C₂₋₆ haloalkenyl, optionallysubstituted heterocyclyl(C₁₋₄)alkyl, C₂₋₆ cyanoalkenyl, phenyl(optionally substituted with fluoro, chloro, bromo, nitro, cyano, C₁₋₆alkyl, C₁₋₂ alkoxy, C₁₋₄ haloalkyl, C₁₋₄ haloalkoxy, methanesulfonyl,methylenedioxy or di(C₁₋₄ alkyl)amino), phenyl(C₁₋₃)alkyl (phenyloptionally substituted with halogen, nitro, cyano, C₁₋₆ alkyl, C₁₋₂alkoxy, C₁₋₄ haloalkyl, C₁₋₄ haloalkoxy, methanesulfonyl, ormethylenedioxy), formyl, optionally substituted heterocyclyl, optionallysubstituted heteroaryl, optionally substituted heteroaryl(C₁₋₄)alkyl,C₁₋₂ alkylcarbonyl, C₁₋₄ alkoxycarbonyl, C¹⁻⁵ alkoxycarbonyl(C₁₋₄)alkyl,a group NR¹⁰R¹¹, a group OR⁸, C₁₋₄ alkoxymethyl, chlorine, a group SR⁹,or a group C(R)¹²═NOR¹³; R⁸ is hydrogen, C₁₋₅ alkyl, C₁₋₄ haloalkyl,C₂₋₄ alkenyl, phenyl (optionally substituted with fluoro, chloro, bromo,nitro, cyano, C₁₋₆ alkyl, C₁₋₂ alkoxy, C₁₋₄ haloalkyl, C₁₋₄ haloalkoxy,methanesulfonyl, or methylenedioxy), phenyl(CH₂) (phenyl optionallysubstituted with fluoro, chloro, bromo, nitro, cyano, C₁₋₆ alkyl, C₁₋₂alkoxy, C₁₋₄ haloalkyl, C₁₋₄ haloalkoxy, methanesulfonyl, ormethylenedioxy), N═C(CH₃)₂; R⁹ is C₁₋₅ alkyl, phenyl (optionallysubstituted with fluoro, chloro, bromo, nitro, cyano, C₁₋₆ alkyl,C₁₋₂alkoxy, C₁₋₄ haloalkyl, C₁₋₄ haloalkoxy, methanesulfonyl,methylenedioxy or di(C₁₋₄ alkyl)amino), C₁₋₂ haloalkyl, cyano,cyanomethyl or C₁₋₂ alkoxycarbonylmethyl; R¹⁰ and R¹¹ are,independently, hydrogen, C₁₋₄ alkyl, C₅₋₆ cycloalkyl, formyl, C₁₋₃alkylcarbonyl, phenoxycarbonyl, C₁₋₂ alkylSO₂ or phenylSO₂; R¹² is C₁₋₂alkyl; and R¹³ is C₁₋₂ alkyl or benzyl.
 8. A compound of formula (I) asclaimed in any one of the preceding claims wherein log₁₀K_(o/w)(calculated usingthe CLOGP3 program, available from BioByte Corp.) ofthe compound is in the range zero to
 8. 9. A compound of formula (I) asclaimed in any one of the preceding claims wherein in the side chainportion of formula (XIX):

no atom having an atomic weight greater than 10 Daltons is more thanfour bond lengths away from at least one atom present in the longestbond path or, when there is a set of longest bond paths, no atom havingan atomic weight greater than 10 Daltons is more than four bond lengthsaway from at least one atom present in each of the longest bond paths.10. Processes for making compounds of formula (I) as defined in claim 1comprising: (i) acylation of a compound of formula (II) by a compound offormula (III):

wherein R¹, R², R³, R⁴, X, Y and n are as described in claim 1; or (ii)acylation of a compound of formula (VIII):

wherein R¹, R², R³, X, Y and n are as described in claim 1, followed bycyclisation of the resultant product.
 11. A fungicidal, insecticidal,acaricidal, molluscicidal or nematicidal composition comprising afungicidally, insecticidally, acaricidally, molluscicidally ornematicidally effective amount of a compound of formula (I) as claimedin claim 1 and a carrier or diluent therefor.
 12. A method of combatingand controlling fungi comprising applying to a plant, to a seed of aplant, to the locus of the plant or seed or to the soil a fungicidallyeffective amount of a compound of formula (I) as claimed in claim 1, ora composition containing a compound of formula (I) as claimed in claim11.
 13. A method of combating and controlling fungi comprising applyingto a plant, to a seed of a plant, to the locus of the plant or seed orto the soil a fungicidally effective amount of a first activeingredient, which is a compound of formula (I) as claimed in claim 1;and a second active ingredient which is azoxystrobin, picoxystrobin,kresoxim-methyl, trifloxystrobin, metominostrobin or SSF129; wherein theweight ratio of the first active ingredient to the second activeingredient is in the range from 5000:1 to 1:10, the relative amounts ofthe first and second active ingredients being such as to produce asynergistic effect.
 14. A method of combating and controlling fungalinfections of plants caused by Plasmopara spp. or Rhizoctonia spp., themethod comprising applying to a plant, to a seed of a plant, to thelocus of the plant or seed or to the soil a fungicidally effectiveamount of a first active ingredient, which is a compound of formula (1)as claimed in claim 1; and a second active ingredient which isfluazinam; wherein the weight ratio of the first active ingredient tothe second active ingredient is in the range from 500:1 to 1:10, therelative amounts of the first and second active ingredients being suchas to produce a synergistic effect.
 15. A method of combating andcontrolling fungal infections of plants caused by Plasmopara spp., themethod comprising applying to a plant, to a seed of a plant, to thelocus of the plant or seed or to the soil a fungicidally effectiveamount of a first active ingredient, which is a compound of formula (1)as claimed in claim 1; and a second active ingredient which isfenamidone or famoxadone; wherein the weight ratio of the first activeingredient to the second active ingredient is in the range from 10:1 to1:10, the relative amounts of the first and second active ingredientsbeing such as to produce a synergistic effect.
 16. A method of combatingand controlling insects, acarines, nematodes or molluscs which comprisesapplying to a pest, to a locus of a pest, or to a plant susceptible toattack by a pest an insecticidaily, acaricidally, nematicidally ormolluscicidally effective amount of a compound of formula (I) as claimedin claim 1, or a composition containing a compound of formula (I) asclaimed in claim
 11. 17. A method as claimed in claim 16 wherein theinsect pests are insect pests of plants.